Synthesis, characterization and cell differentiation of a new class of injectable hydrogels, thermosensitive and biodegradable

• Grant number: 14/11858-9
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2014
• End date: September 30, 2016
• Field of knowledge: Engineering - Biomedical Engineering - Medical Engineering
• Principal Investigator: Eliana Aparecida de Rezende Duek
• Grantee: Eliana Aparecida de Rezende Duek
• Host Institution: Faculdade de Ciências Médicas e da Saúde (FCMS). Pontifícia Universidade Católica de São Paulo (PUC-SP). Sorocaba , SP, Brazil
• Associated researchers: Rômulo Tadeu Dias de Oliveira

Abstract

Hydrogels have been widely studied, especially as injectable materials for applications as biomaterials. These hydrogels may possess thermosensitive features near body temperature (LCST - Lower Critical Solution Temperature - around 37ºC), in addition to rapid gelation, which allows it use as carrier drugs, cells or cell growth factors as injections. The current challenge is to make these materials biodegradables and suitable the mechanical properties for their use. The aim of this study will be to synthesize hydrogels of poly(N-iropropylacrylamide) (PNIPAAm) from a new class of macromer consisting of 2-hydroxyethyl methacylate (HEMA), poly(L-co-D,L lactic acid) and trimethylene carbonate (PLDLA-co-TMC) in order to synthesized material with inherent characteristics such as biodegradability and mechanical properties compatible to required applications in the field of tissue engineering. In addition, another aim for the hydrogel will assess your role as substrate in the differentiation of bone marrow-derived mesenchymal stem cells of rabbits in cardiomyocytes, aiming future application in cardiac tissue engineering. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KOMATSU, DANIEL; MISTURA, DANIEL V.; MOTTA, ADRIANA; DOMINGUES, JULIANA A.; HAUSEN, MOEMA A.; DUEK, ELIANA. Development of a membrane of poly (L-co-D,L lactic acid-co-trimethylene carbonate) with aloe vera: An alternative biomaterial designed to improve skin healing. JOURNAL OF BIOMATERIALS APPLICATIONS, v. 32, n. 3, p. 311-320, SEP 2017. (15/06883-7, 14/11858-9)