Antioxidant potential of green tea in the quiescence/mobilization of hematopoietic cells mediated by oxidative stress and standardization of an experimental model for leukemia

• Grant number: 14/08939-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2014
• End date: September 30, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Sara Teresinha Olalla Saad
• Grantee: Cristiane Okuda Torello
• Host Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 11/51959-0 - Biology of neoplastic diseases of bone marrow, AP.TEM

Abstract

Green tea obtained by treating the leaves of Camellia sinensis plant has been consumed by population as a beverage for thousands of years due to its therapeutic properties observed over time. Polyphenols are the main chemical constituents of the plant and the green tea. Its antioxidant property has been identified as the major contributing factor in the prevention and / or treatment of various chronic diseases including cardiovascular disease, diabetes and cancer. Thus, our proposal is to investigate the effects of green tea on the quiescence and mobilization of hematopoietic cells populations, through the study of the coagulation signaling pathway, related to oxidative stress. Furthermore, we aim to standardize an experimental model of leukemia for further investigation of the effects of green tea on the processes of cell death and survival. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TORELLO, CRISTIANE OKUDA; ALVAREZ, MARISA CLAUDIA; OLALLA SAAD, SARA T.. Polyphenolic Flavonoid Compound Quercetin Effects in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes. Molecules, v. 26, n. 19, OCT 2021. (17/21801-2, 14/08939-7)

TORELLO, CRISTIANE OKUDA; SHIRAISHI, RODRIGO NAOTO; DELLA VIA, FERNANDA ISABEL; LOPES DE CASTRO, TAMARA CRISTINA; LONGHINI, ANA LEDA; SANTOS, IRENE; BOMBEIRO, ANDRE LUIS; ARAUJO SILVA, CLEIDE LUCIA; DE SOUZA QUEIROZ, MARY LUCI; REGO, EDUARDO MAGALHAES; et al. Reactive oxygen species production triggers green tea-induced anti-leukaemic effects on acute promyelocytic leukaemia model. Cancer Letters, v. 414, p. 116-126, FEB 1 2018. (11/51959-0, 14/08939-7)