Evaluation of glutamine as modulator of c-Rel and NFkB factors in macrophages and lymphocytes in a dietary restriction model

• Grant number: 14/14204-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: November 01, 2014
• End date: June 30, 2017
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Ricardo Ambrósio Fock
• Grantee: Dalila Cunha de Oliveira
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 15/02610-6 - Evaluation of glutamine as modulator of the transcription factor NF-kB and c-Rel in macrophages and lymphocytes from IL-10 knock out mice subjected to dietary restriction, BE.EP.DR

Abstract

The development of an appropriate immune response is very important for the maintenance of homeostasis, a series of processes are triggered from the first contact with pathogenic microorganisms to the effectiveness of the immune memory response. For these processes occur properly, nutrients are necessary, including glutamine that plays roles as a substrate for energy supply, and nitrogen supply to genetic material formation. Dietary restriction has been studied as a potential beneficial in the treatment of cancer and increased longevity of some of animals species. Given the importance of glutamine as a nutrient and the potential of dietary restriction to modulate the immune response, we propose in this project evaluate the production of cytokines (IL-1, IL-12, IL-8, IL-10 and TNF-alpha), as well as the expression of NFKB, c-Rel, B7 and CD28 on macrophages and lymphocytes in vitro, supplemented with different concentrations of glutamine, from mice submitted with dietary restriction. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

OLIVEIRA, Dalila Cunha de. Proinflammatory cytokines gene expression control mediated by IL-10. Participation of IL-10 on inflammatory response exerted by glutamine and dietary restriction. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.