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Dietary supplementation of glutamine on growth performance, intestinal morphology, hematic, enzymatic and immunological responses of the Nile tilapia subjected to bacterial challenge

Grant number: 15/23777-6
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 01, 2016
Effective date (End): August 31, 2016
Field of knowledge:Agronomical Sciences - Animal Husbandry - Animal Nutrition and Feeding
Principal researcher:Margarida Maria Barros
Grantee:Pedro Luiz Pucci Figueiredo de Carvalho
Supervisor abroad: Delbert M. Gatlin
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Research place: Texas A&M University, United States  
Associated to the scholarship:14/01973-5 - Dietary supplementation of glutamine on growth performance, intestinal morphology, hematic, enzymatic and immunological responses of the Nile Tilapia subjected to bacterial challenge, BP.DR

Abstract

Studies have shown that under appropriate conditions, glutamine is essential for cell proliferation, acting as a respiratory fuel for enterocytes and lymphocytes, with beneficial effects on the function of stimulated immune cells. Thus, specific components of both the innate and adaptive immune systems of Nile tilapia will be evaluated after supplementation of culture media with glutamine (GLN). Primary cell cultures of head-kidney macrophages will be used for phagocytic and bactericidal assays against Streptococcus iniae. Additionally, proliferation assays will be conducted with peripheral blood lymphocytes (PBL) exposed to non-specific mitogens. To indirectly assess amino acid utilization of both macrophages and PBL, amino acid levels will be evaluated in the basal medium before and after activation or mitogenic exposure.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARVALHO, PEDRO L. P. F.; YAMAMOTO, FERNANDO Y.; BARROS, MARGARIDA M.; GATLIN, III, DELBERT M. L-glutamine in vitro supplementation enhances Nile tilapia Oreochromis niloticus (Linnaeus, 1758) leukocyte function. FISH & SHELLFISH IMMUNOLOGY, v. 80, p. 592-599, SEP 2018. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.