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The effects of erythropoietin and a novel erythropoietin variant on cognitive deficits and hippocampal neurodegeneration in transgenic animal models of Alzheimer's Disease

Grant number: 14/18795-2
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 01, 2015
Effective date (End): February 29, 2016
Field of knowledge:Humanities - Psychology - Physiological Psychology
Principal Investigator:Rosana Mattioli
Grantee:Fernanda Daher Pitta
Supervisor: Hannelore Ehrenreich
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Research place: Max Planck Society, Gottingen, Germany  
Associated to the scholarship:13/10761-9 - Involvement of neural histamine in learned helplessness, aversive memory and postnatal neurogenesis of mice, BP.DR

Abstract

Recently, transgenic mice expressing (A beta)4-42 peptide (Tg4-42 transgenic line) have been generated (Bouter et al., 2013) as a transgenic mouse model of Alzheimer's disease (AD). These mutants developed a massive CA1 pyramidal neuron loss in the hippocampus. This hippocampal neurodegeneration was associated with age-dependent spatial learning deficits in the Morris water-maze. In the present project, we wish to extend these findings by investigating different types of Alzheimer-relevant cognitive domains, object memory including novel object recognition, object-place memory, temporal order memory (TOM) and episodic-like memory (ELM). We will also examine whether chronic erythropoietin (EPO) treatment would be effective in ameliorating cognitive deficits in these mice. In all experiments, we will in parallel test mice of the 5xFAD transgenic line as an established Alzheimer model. The aim of this project is to investigate whether pre- or early symptomatic EPO treatment can block or delay the cognitive deficits in two transgenic mouse models of Alzheimer's disease. Furthermore, the effect of EPO and an EPO variant with no major side effects on hippocampal pathology in Alzheimer's mice will be investigated. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
WINKLER, DANIELA; DAHER, FERNANDA; WUESTEFELD, LIANE; HAMMERSCHMIDT, KURT; POGGI, GIULIA; SEELBACH, ANNA; KRUEGER-BURG, DILJA; VAFADARI, BEHNAM; RONNENBERG, ANJA; LIU, YANLING; et al. Hypersocial behavior and biological redundancy in mice with reduced expression of PSD95 or PSD93. Behavioural Brain Research, v. 352, p. 11-pg., . (14/18795-2)
WINKLER, DANIELA; DAHER, FERNANDA; WUESTEFELD, LIANE; HAMMERSCHMIDT, KURT; POGGI, GIULIA; SEELBACH, ANNA; KRUEGER-BURG, DILJA; VAFADARI, BEHNAM; RONNENBERG, ANJA; LIU, YANLING; et al. Hypersocial behavior and biological redundancy in mice with reduced expression of PSD95 or PSD93. Behavioural Brain Research, v. 352, n. SI, p. 35-45, . (14/18795-2)
KRUEGER-BURG, DILJA; WINKLER, DANIELA; MITKOVSKI, MISO; DAHER, FERNANDA; RONNENBERG, ANJA; SCHLUETER, OLIVER M.; DERE, EKREM; EHRENREICH, HANNELORE. The SocioBox: A Novel Paradigm to Assess Complex Social Recognition in Male Mice. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 10, . (14/18795-2)

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