| Grant number: | 13/20952-6 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | November 01, 2014 |
| End date: | August 31, 2017 |
| Field of knowledge: | Health Sciences - Pharmacy - Toxicological Analysis |
| Agreement: | Coordination of Improvement of Higher Education Personnel (CAPES) |
| Principal Investigator: | Tania Marcourakis |
| Grantee: | Mariana Sayuri Berto Udo |
| Host Institution: | Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract The growing number of crack users is already considered a great public health issue, not only in Brazil but all around the world. Crack is widely associated with sexual diseases due to prostitution, violent and criminal behavior, medical and psychiatric complications and also increase in morbidity and mortality rate. The choose of smokable cocaine is due to its intense effects. The crack users are also under the effects of cocaine pyrolysis product, the anhydroecgonine methyl ester (AEME), but the knowledge about the effects of AEME is scarce. There are evidences that the acute and chronic cocaine use leads to neurodegeneration. There are many mechanisms that lead to a neurodegeneration. About crack exposure, recently studies have shown that the degenerative consequences shown by the users could be due to neuronal cells necrosis and/or apoptosis in several brain areas. The real participation of AEME in those processes still remains unclear. Therefore, the aim of this study is to investigate the involvement of cocaine, AEME and the association of both on the morphologic and physiologic conditions of hippocampus neurons in vitro, seeking the process of cellular death pathways occurring in crack exposure. (AU) | |
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