Metabolomic and chemometric approach for the study of chemotaxonomy, authentication and quality control of the species of the subfamily Barnadesioideae (Asteraceae)

• Grant number: 14/16850-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: November 01, 2014
• End date: January 31, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Fernando Batista da Costa
• Grantee: Gari Vidal Ccana Ccapatinta
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The species of the subfamily Barnadesioideae (Asteraceae) comprise a monophyletic group with ca. 91 species entirely restricted to South America. Phylogenetic studies based on morphology and DNA demonstrate the importance of this subfamily in understanding the evolutionary relationships of the Asteraceae family. In addition, several species of this subfamily are included in traditional medicine systems, especially in Andean countries, where they are used for their anti-inflammatory, antimicrobial and antitussive properties, among many others. Although the species of the subfamily Barnadesioideae present a broad commercialization in marketplaces and medicinal plant markets, so far there are few reports of analytical methodologies for the authentication and quality control of plant material and marketed phytomedicines. Considering the advent of the metabolomics as a modern approach applied to the analysis of plant matrices and medicinal plants, this project aims to explore the chemotaxonomy, authentication and quality control of the species of the subfamily Barnadesioideae (Asteraceae) via metabolomic studies using hyphenated techniques (UHPLC-UV-MS) and chemometrics.

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CCANA-CCAPATINTA, GARI V.; MONGE, MARCELO; FERREIRA, PAOLA L.; DA COSTA, FERNANDO B.. Chemistry and medicinal uses of the subfamily Barnadesioideae (Asteraceae). PHYTOCHEMISTRY REVIEWS, v. 17, n. 3, p. 471-489, JUN 2018. (14/26866-7, 14/16850-6)

CCANA-CCAPATINTA, V, GARI; PADILLA-GONZALEZ, GUILLERMO F.; FERREIRA, PAOLA L.; MONGE, MARCELO; CASOTI, ROSANA; CORRADIN, MARINA D.; SEMIR, JOAO; GROPPO, MILTON; DA COSTA, FERNANDO B.. Phenolic Profiling of Medicinal Species of Chuquiraga, Asteraceae, by HPLC Fingerprinting. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 31, n. 5, SEP 2021. (14/16850-6, 14/26866-7)

CCANA-CCAPATINTA, GARI V.; SAMPAIO, BRUNO L.; DOS SANTOS, JR., FERNANDO M.; BATISTA, JR., JOAO M.; DA COSTA, FERNANDO B.. Absolute configuration assignment of caffeic acid ester derivatives from Tithonia diversifolia by vibrational circular dichroism: the pitfalls of deuteration. TETRAHEDRON-ASYMMETRY, v. 28, n. 12, p. 1823-1828, DEC 15 2017. (15/07089-2, 11/13361-6, 14/26866-7, 14/25222-9, 14/16850-6, 16/23794-0)

CCANA-CCAPATINTA, GARI V.; FEITAS, JOLINDO A.; MONGE, MARCELO; FERREIRA, PAOLA DE L.; SEMIR, JOAO; GROPPO, MILTON; DA COSTA, FERNANDO B.. Metabolomics and chemophenetics support the new taxonomy circumscription of two South America genera (Barnadesioideae, Asteraceae). PHYTOCHEMISTRY LETTERS, v. 40, p. 89-95, DEC 2020. (16/06260-2, 14/16850-6, 14/26866-7)

CCANA-CCAPATINTA, V, GARI; FERREIRA, PAOLA L.; GROPPO, MILTON; DA COSTA, FERNANDO B.. Caffeic acid ester derivatives and flavonoids of genus Arnaldoa (Asteraceae, Barnadesioideae). Biochemical Systematics and Ecology, v. 86, OCT 2019. (16/06260-2, 14/26866-7, 14/16850-6)

CCANA-CCAPATINTA, GARI, V; PADILLA-GONZALEZ, GUILLERMO F.; FERREIRA, PAOLA L.; MONGE, MARCELO; SEMIR, JOAO; GROPPO, MILTON; COSTA, FERNANDO B. DA. High-Resolution Liquid Chromatography-Mass Spectrometry-Based Metabolomics for the Classification of Chuquiraga (Barnadesioideae, Asteraceae): New Phenylpropanoid Derivatives as Chemical Markers for Chuquiraga spinosa. Journal of Natural Products, v. 86, n. 4, p. 11-pg., 2023-03-13. (14/16850-6, 14/26866-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CCAPATINTA, Gari Vidal Ccana. Metabolomics studies of the subfamily Barnadesioideae (Asteraceae). 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.