Metabolomic and chemometric approach for the study of chemotaxonomy, authentication and quality control of the species of the subfamily Barnadesioideae (Asteraceae)

• Grant number: 14/16850-6
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): November 01, 2014
• Effective date (End): January 31, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal researcher: Fernando Batista da Costa
• Grantee: Gari Vidal Ccana Ccapatinta
• Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The species of the subfamily Barnadesioideae (Asteraceae) comprise a monophyletic group with ca. 91 species entirely restricted to South America. Phylogenetic studies based on morphology and DNA demonstrate the importance of this subfamily in understanding the evolutionary relationships of the Asteraceae family. In addition, several species of this subfamily are included in traditional medicine systems, especially in Andean countries, where they are used for their anti-inflammatory, antimicrobial and antitussive properties, among many others. Although the species of the subfamily Barnadesioideae present a broad commercialization in marketplaces and medicinal plant markets, so far there are few reports of analytical methodologies for the authentication and quality control of plant material and marketed phytomedicines. Considering the advent of the metabolomics as a modern approach applied to the analysis of plant matrices and medicinal plants, this project aims to explore the chemotaxonomy, authentication and quality control of the species of the subfamily Barnadesioideae (Asteraceae) via metabolomic studies using hyphenated techniques (UHPLC-UV-MS) and chemometrics.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CCANA-CCAPATINTA, V, GARI; PADILLA-GONZALEZ, GUILLERMO F.; FERREIRA, PAOLA L.; MONGE, MARCELO; CASOTI, ROSANA; CORRADIN, MARINA D.; SEMIR, JOAO; GROPPO, MILTON; DA COSTA, FERNANDO B. Phenolic Profiling of Medicinal Species of Chuquiraga, Asteraceae, by HPLC Fingerprinting. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, SEP 2021. Web of Science Citations: 0.

CCANA-CCAPATINTA, GARI V.; FEITAS, JOLINDO A.; MONGE, MARCELO; FERREIRA, PAOLA DE L.; SEMIR, JOAO; GROPPO, MILTON; DA COSTA, FERNANDO B. Metabolomics and chemophenetics support the new taxonomy circumscription of two South America genera (Barnadesioideae, Asteraceae). PHYTOCHEMISTRY LETTERS, v. 40, p. 89-95, DEC 2020. Web of Science Citations: 0.

CCANA-CCAPATINTA, V, GARI; FERREIRA, PAOLA L.; GROPPO, MILTON; DA COSTA, FERNANDO B. Caffeic acid ester derivatives and flavonoids of genus Arnaldoa (Asteraceae, Barnadesioideae). Biochemical Systematics and Ecology, v. 86, OCT 2019. Web of Science Citations: 0.

CCANA-CCAPATINTA, GARI V.; MONGE, MARCELO; FERREIRA, PAOLA L.; DA COSTA, FERNANDO B. Chemistry and medicinal uses of the subfamily Barnadesioideae (Asteraceae). PHYTOCHEMISTRY REVIEWS, v. 17, n. 3, p. 471-489, JUN 2018. Web of Science Citations: 1.

CCANA-CCAPATINTA, GARI V.; SAMPAIO, BRUNO L.; DOS SANTOS, JR., FERNANDO M.; BATISTA, JR., JOAO M.; DA COSTA, FERNANDO B. Absolute configuration assignment of caffeic acid ester derivatives from Tithonia diversifolia by vibrational circular dichroism: the pitfalls of deuteration. TETRAHEDRON-ASYMMETRY, v. 28, n. 12, p. 1823-1828, DEC 15 2017. Web of Science Citations: 3.