Effect of ACE I/D and ACTN3 C>T genetic polymorphisms in response variability to a multicomponent exercise training on physical capacities in women aged 50-70 years

• Grant number: 14/20785-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2014
• End date: November 30, 2015
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Carlos Roberto Bueno Júnior
• Grantee: Vitor Nolasco de Moraes
• Host Institution: Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Genetic polymorphisms are variations in DNA sequence that affect more than 1% of the world population (MATOS, 2005). Polymorphisms in angiotensin converting enzyme (ACE) genes and alpha-actinin protein 3 (ACTN3) can explain, at least in part, why some people have more benefits than others performing the same exercise training. Studies in that area are interesting because in the future it will be possible to prescribe training according to genetic characteristics of each person. Objective: Measure the effect of I/D and R/X ACTN3 polymorphisms in response variability to a multicomponent exercise training in strength, power strength, aerobic capacity, flexibility and agility in women aged 50-70 years. Methods: Women will be invited to participate in the study and will be shared in groups according to each genotype (ECA II, ID, DD and ACTN3 XX, RR/RX). It will be carry out a pilot sample with n=10 for each group in order to evaluate the data variability of the results, allowing to calculate the sample size (SINGER and ANDRADE, 2000). It will be applied the Rikli and Jones and AAHPERD tests to measure physical capacities before and after training. The multicomponent training will last for 12 weeks, twice a week, 90 min each session. For data analysis it will be used Kolmogorov-Smirnov, Levene and Anova tests - when necessary, the Tukey post hoc will be performed.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MORAES, V. N.; TRAPE, A. A.; FEREZIN, L. P.; GONCALVES, T. C. P.; MONTEIRO, C. P.; BUENO JUNIOR, C. R.. Association of ACE ID and ACTN3 C > T genetic polymorphisms with response to a multicomponent training program in physical performance in women from 50 to 70 years. SCIENCE & SPORTS, v. 33, n. 5, p. 282-290, OCT 2018. (14/20785-5)