Histological and histomorphometric evaluation of chitosan, collagen and hydroxyapatite composites as bone graft substitute in a sheep tibial defect

• Grant number: 14/16670-8
• Support Opportunities: Scholarships in Brazil - Master
• Start date: November 01, 2014
• End date: May 31, 2016
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: André Luis do Valle de Zoppa
• Grantee: Nicole Fidalgo Paretsis
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Bone defects are commonly found in veterinary medicine through different illnesses such as trauma or metabolic changes. Often, intervention is required during tissue repair. Biomaterials have been developed to this objective. Evaluating cell behavior with the biomaterial in vivo is essential. Studying morphological and functional unit of tissue, it is possible to evaluate the quantity and the quality of new formed tissue. Currently in orthopedic studies, sheep are being used as animal model for implant biomaterial reserach. From bone defects in sheep experimentally performed, will be implanted biomaterials based on chitosan, hydroxyapatite and collagen. After 60 days, by biopsy, will be performed histomorphometry and transmission microscopy. The newly formed tissue will be described, evaluated and compared. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PARETSIS, Nicole Fidalgo. Histological and histomorphometric evaluation of the bone regeneration with the use of chitosan, collagen and hydroxyapatite composites as a bone substitute in bone defect induced in the tibia of sheep. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.