Impact of mitochondrial dysfunction on skin aging

• Grant number: 14/17270-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2015
• End date: December 31, 2016
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Alicia Juliana Kowaltowski
• Grantee: Julia Peloggia de Castro
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The skin is an organ in constant renewal and its homeostasis is maintained mainly by resident stem cells. During the aging process, the regenerative potential declines due to impairment of these cells, therefore reducing the capacity of tissues to respond to damage or stress. The maintenance of tissue homeostasis is a highly energy-demanding process and mitochondria are the main organelle responsible for the ATP production in the eukaryotic cell. The aim of this work is to characterize the bioenergetics changes and mitochondrial contribution to skin aging, comparing the stem cells with the differentiated compartment in both young and old mice.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AMIGO, IGNACIO; DA CUNHA, FERNANDA M.; FORNI, MARIA FERNANDA; GARCIA-NETO, WILSON; KAKIMOTO, PAMELA A.; LUEVANO-MARTINEZ, LUIS A.; MACEDO, FELIPE; MENEZES-FILHO, SERGIO L.; PELOGGIA, JULIA; KOWALTOWSKI, ALICIA J.. Mitochondrial form, function and signalling in aging. Biochemical Journal, v. 473, n. 20, p. 3421-3449, OCT 2016. (15/15526-3, 10/51906-1, 14/17270-3, 13/04919-9, 15/25776-7, 13/07937-8)

FORNI, MARIA FERNANDA; CHAUSSE, BRUNO; PELOGGIA, JULIA; KOWALTOWSKI, ALICIA J.. Bioenergetic profiling in the skin. EXPERIMENTAL DERMATOLOGY, v. 25, n. 2, p. 147-148, FEB 2016. (10/51906-1, 13/04871-6, 13/07937-8, 14/17270-3)

FORNI, MARIA FERNANDA; PELOGGIA, JULIA; TRUDEAU, KYLE; SHIRIHAI, ORIAN; KOWALTOWSKI, ALICIA J.. Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics. Stem Cells, v. 34, n. 3, p. 743-755, MAR 2016. (10/51906-1, 13/04871-6, 13/07937-8, 14/17270-3)

AMIGO, IGNACIO; DA CUNHA, FERNANDA M.; FORNI, MARIA FERNANDA; GARCIA-NETO, WILSON; KAKIMOTO, PAMELA A.; LUEVANO-MARTINEZ, LUIS A.; MACEDO, FELIPE; MENEZES-FILHO, SERGIO L.; PELOGGIA, JULIA; KOWALTOWSKI, ALICIA J.. Mitochondrial form, function and signalling in aging. Biochemical Journal, v. 473, p. 29-pg., 2016-10-01. (13/07937-8, 13/04919-9, 15/15526-3, 14/17270-3, 10/51906-1, 15/25776-7)

FORNI, MARIA FERNANDA; PELOGGIA, JULIA; BRAGA, TARCIO T.; ORTEGA CHINCHILLA, JESUS EDUARDO; SHINOHARA, JORGE; NAVAS, CARLOS ARTURO; SARAIVA CAMARA, NIELS OLSEN; KOWALTOWSKI, ALICIA J.. Caloric Restriction Promotes Structural and Metabolic Changes in the Skin. CELL REPORTS, v. 20, n. 11, p. 2678-2692, SEP 12 2017. (10/51906-1, 14/17270-3, 12/02270-2, 13/04871-6, 14/16320-7, 13/07937-8)