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Functional analysis of differentially expressed genes in lung tumors induced by K-Ras oncogenic form in the presence and absence of subunit p65 of NF-kB transcription factor

Grant number: 14/25834-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2015
Effective date (End): September 30, 2015
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal researcher:Daniela Sanchez Basseres
Grantee:Thalita Bueno Corrêa
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Given that the NF-kB subunit p65 plays an important role in oncogenic Ras-induced neoplastic transformation, including K-Ras-induced lung transformation, it is crucial to identify p65-regulated genes that promote oncogenesis. Based on the hypothesis that p65 regulates potential therapeutic targets in the lung, our experimental approach will include identification of differentially expressed genes in K-Ras-induced murine lung tumors in the presence and absence of p65. The rationale for this approach is that, once it is completed, it will provide critical information about the molecular mechanisms involved in KRas-induced malignant transformation. This knowledge will be of great value for the development of more effective therapeutic strategies for lung cancer patients. Once the proposed studies are finalized, we expect to have identified new potential therapeutic targets for lung cancer. This would be an important finding because it would allow the design of new pharmacological approaches to block oncogenic KRas activity in lung cancer therapy.