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Horizontal gene transfer of genes related to niche adaptation in prokaryotes

Grant number: 14/23975-0
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Start date: April 01, 2015
End date: March 31, 2016
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:João Carlos Setubal
Grantee:Luiz Thibério Lira Diniz Rangel
Supervisor: Johann Peter Gogarten
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Institution abroad: University of Connecticut (UCONN), United States  
Associated to the scholarship:12/17196-2 - Phylogenomic Networks and Lateral Gene Transfer, BP.DR

Abstract

Horizontal Gene Transfer processes have a major role on prokaryotic evolution and is the main mechanism for acquisition of new genes. The horizontal transfer of niche-adaptive genes are known to have a great impact in speciation, and their transfer is needed for the colonization of new habitats. One of the most important class of niche-adaptive genes is the Type III Secretion System (machinery and effectors), which allows the bacterial association with a wide variety of hosts. We intend to identify Horizontal Gene Transfer events of Type III Secretion System effectors related to niche adaptation of Aeromonas spp. and which effectors are related to which habitats. The obtained results will improve the knowledge of how pathogenic bacteria can suddenly infect new hosts, what mechanisms are related to the acquisition of this hability and what are the transfer trends of effectors among and/or within niches. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RANGEL, LUIZ THIBERIO; MARDEN, JEREMIAH; COLSTON, SOPHIE; SETUBAL, JOAO CARLOS; GRAF, JOERG; GOGARTEN, JOHANN PETER. Identification and characterization of putative Aeromonas spp. T3SS effectors. PLoS One, v. 14, n. 6, . (14/23975-0, 12/17196-2)