Immunological study of the interaction between dendritic cells an biopolymeric nanofibers

• Grant number: 15/00771-2
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: March 01, 2015
• End date: December 23, 2015
• Field of knowledge: Engineering - Biomedical Engineering - Medical Engineering
• Principal Investigator: Luiz Henrique Capparelli Mattoso
• Grantee: Rafaella Takehara Paschoalin
• Supervisor: Martin Zenke
• Host Institution: Embrapa Instrumentação Agropecuária. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil
• Institution abroad: RWTH Aachen University, Germany
• Associated to the scholarship: 13/03474-3 - Development of polymeric nanostructures for application in tissue engineering, BP.DR

Abstract

Biomaterials are used in many medical applications, ranging from scaffolds for tissue regeneration to drug delivery systems. However, biomaterials often cause inflammatory reactions because they profoundly alter the homeostasis of host immune cells, such as dendritic cells (DCs). Thus, there is a major need to understand how biomaterials affect the immune function of DCs. In this project, we will analyse the chemical and physical influence of poly(lactic acid) (PLA) and PLA/polyethylene glycol (PLA/PEG) blends on functional properties in DCs. Our findings should be useful for designing structures of scaffolds with more preferable biocompatible properties. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PASCHOALIN, RAFAELLA T.; TRALDI, BRUNA; AYDIN, GUELCAN; OLIVEIRA, JULIANO E.; MITTEN, STEPHAN; MATTOSO, LUIZ H. C.; ZENKE, MARTIN; SECHI, ANTONIO. Solution blow spinning fibres: New immunologically inert substrates for the analysis of cell adhesion and motility. Acta Biomaterialia, v. 51, p. 161-174, MAR 15 2017. (15/00771-2, 13/03474-3)