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Evaluation of cardiac structural changes induced by salt overload in male Wistar rats

Grant number: 14/16249-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2014
Effective date (End): November 30, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Joel Claudio Heimann
Grantee:Veronica Favoni Rocha
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The cardiac hypertrophy is an apparition that follow hypertension, having one of the highlight motive the high salt intake, where it is observed a increased of structural and contract proteins of myocytes, being together with the enhanced of interstitial collagen.The high salt intake changes the running of the Renin-Angiotensin System (RAS), which is a homeostatic system that controls the corporeal liquid, electrolytic balance, blood pressure and neuronal and endocrine functions related with the vascular control, by a cascade. This cascade obtain like a final peptide the angiotensin II that act on two principal receptors (AT1 and AT2), which in turn act by distinct ways.With the objective to understand better the AT2 receptor paper about the hypertrophy and cardiac fibrosis in overburden models of salt, male Wistar mice will be fed with a normosodic diet (n=16) or high salt diet (n=32) since the ablactation into the 18ª age week. The high salt diet group will be divided between two groups, where one of them will receive a treatment with compound 21 (1mg/kg/day, n=16), AT2 receptor agonist. Will be realized the following evaluations: weight body, caudal arterial pressure, feed consumption, water intake, urinary volume, urinary sodium and potassium, transverse diameter of cardiomyocytes and quantification of fibrosis.

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