Osteocalcin action on lipid accumulation via GLUT2/SREBP-1c in hepatocytes and hepatic tissue of obese mice

• Grant number: 15/01576-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2015
• End date: December 31, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Daniela Tomie Furuya
• Grantee: José Augusto Cipriano Guedes
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 13/18841-1 - Regulation of glucose metabolism by the bone: role of osteocalcin in insulin resistance and inflammation of adipose tissue and liver, AP.JP

Abstract

The uncarboxylated form of osteocalcin (uOCN), an osteoblat-derived protein, acts as a homone that has a positive effect on insulin secretion and sensitivity, as well as on fat metabolism. These observations led to the fascinating discovery of bone as an endocrine gland. Treatment with uOCN prevents hepatic steatosis in obese animal; however, little is known about the molecular mechanism of uOCN actions on steatosis. Considering the evidences that the glucose transporter GLUT2 and the transcriptional factor SREBP-1c, which regulates the expression of the gene that codificates to GLUT2 protein, have an important role on the development of hepatic steatosis on obesity, the objective of the present project is to investigate if uOCN reduces lipid accumulation via GLUT2/SREBP-1c in hepatocytes and liver os obese mice.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUEDES, J. A. C.; ESTEVES, J., V; MORAIS, M. R.; ZORN, T. M.; FURUYA, D. T.. Osteocalcin improves insulin resistance and inflammation in obese mice: Participation of white adipose tissue and bone. BONE, v. 115, p. 15-pg., 2018-10-01. (14/10007-5, 13/18841-1, 15/01576-9)

GUEDES, J. A. C.; ESTEVES, V, J.; MORAIS, M. R.; ZORN, T. M.; FURUYA, D. T.. Osteocalcin improves insulin resistance and inflammation in obese mice: Participation of white adipose tissue and bone. BONE, v. 115, n. SI, p. 68-82, OCT 2018. (13/18841-1, 15/01576-9, 14/10007-5)

GUEDES, J. A. C.; ESTEVES, J. V.; MORAIS, M. R. T.; ZORN, T. M. T.; MACHADO, U. F.; FURUYA, D. T.. MECHANISMS FOR OSTEOCALCIN-IMPROVED INSULIN RESISTANCE. DIABETES TECHNOLOGY & THERAPEUTICS, v. 20, p. 1-pg., 2018-02-01. (14/10007-5, 13/18841-1, 12/04831-1, 15/01576-9)