Studies employing isoxazol-5-ones for the preparation of important building blocks in organic synthesis

• Grant number: 15/01331-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2015
• End date: December 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Igor Dias Jurberg
• Grantee: Camila Sartori
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This project aims at the development of two independent studie. In the first one, we plan to execute an asymmetric conjugate addition of monosubstituted isoxazol-5-ones to different alpha,beta-unsaturated carbonyl compounds. In the second project, we aim the preparation of alpha-fluorinated and alpha-trifluoromethylated alkynes In both projects, the obtained compounds will be employed in further transformations, in order to demonstrate their usefulness in organic synthesis.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

STIVANIN, MATEUS L.; DUARTE, MARCELO; SARTORI, CAMILA; CAPRETI, NAYLIL M. R.; ANGOLINI, CELIO F. F.; JURBERG, IGOR D.. An Aminocatalyzed Michael Addition/Iron-Mediated Decarboxylative Cyclization Sequence for the Preparation of 2,3,4,6-Tetrasubstituted Pyridines: Scope and Mechanistic Insights. Journal of Organic Chemistry, v. 82, n. 19, p. 10319-10330, OCT 6 2017. (15/20809-4, 16/12749-4, 14/15718-7, 15/01331-6)