Development of patches containing the association of artemether - lumefantrine for the treatment of malaria caused by Plasmodium falciparum

• Grant number: 14/16008-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: April 01, 2015
• End date: February 28, 2019
• Field of knowledge: Health Sciences - Pharmacy
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Mary Ann Foglio
• Grantee: Fabiana Volpe Zanutto
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 16/18384-8 - Development of patches containing the association of artemether-lumefantrine for the treatment of malaria caused by Plasmodium falciparum, BE.EP.DR

Abstract

Malaria is one of the most important parasitoids in the world, affecting approximately 300 million people each year. This is an acute feverish infectious disease transmitted by Anopheles genus vector, whose agents are the Plasmodium sp. Malaria has a conventional therapy, which is often hampered, because the patients do not undergo the medical treatment properly, thus favoring the Plasmodium resistance. Considering the small quantity of innovative antimalarial medicine approved in the last decades, the pursuit of more effective and less toxic antimalarial drugs and the design of pharmaceutical systems based on nanotechnology could be considered as the main processes of fighting this disease. Thus, the aim of this work is the development of a transdermal patch to treat malaria, in order to increase the patient's adhesion to the therapy and to help reducing the rates of mortality due to this parasitoids worldwide. Artemether and free lumefantrine or encapsulated into nanoparticles lumefantrine will be used as antimalarial agents. For the development of nanoparticles, intercrossing or self assembly techniques will be used. The transdermal systems will be designed into different releasing capabilities. Quantitative and qualitative analyzes of the substances present in the patch will be made through high performance liquid chromatography or mass spectrometry. The nanoparticles will be evaluated using dynamic light scattering and scanning electronic microscopy techniques. The permeability to vapor water, the cutaneous permeation, stability tests and microbiological assessments will also be analyzed. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ELISEI, L. M. S.; MORAES, T. R.; MALTA, I. H.; CHARLIE-SILVA, I.; SOUSA, I. M. O.; VERAS, F. P.; FOGLIO, M. A.; FRACETO, L. F.; GALDINO, G.. Antinociception induced by artemisinin nanocapsule in a model of postoperative pain via spinal TLR4 inhibition. INFLAMMOPHARMACOLOGY, v. 28, n. 6, p. 1537-1551, DEC 2020. (14/16008-3)

VOLPE-ZANUTTO, FABIANA; FONSECA-SANTOS, BRUNO; MCKENNA, PETER E.; PAREDES, ALEJANDRO J.; DAVILA, JOSE LUIS; MCCRUDDEN, MAELIOSA T. C.; PEREIRA TANGERINA, MARCELO MARUCCI; FIGUEIREDO, MARIANA CECCHETO; VILEGAS, WAGNER; BRISIBE, ANDI; et al. Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs artemether-lumefantrine. Biomedical Materials, v. 16, n. 6, NOV 1 2021. (16/18384-8, 14/16008-3)

ZANUTTO, FABIANA VOLPE; MCALISTER, EMMA; PEREIRA TANGERINA, MARCELO MARUCCI; FONSECA-SANTOS, BRUNO; COSTA SALLES, TAIS HELENA; OLIVEIRA SOUZA, ILZA MARIA; BRISIBE, ANDI; VILEGAS, WAGNER; CHORILLI, MARLUS; D'AVILA, MARCOS AKIRA; et al. Semisynthetic Derivative of Artemisia annua-Loaded Transdermal Bioadhesive for the Treatment of Uncomplicated Malaria Caused by Plasmodium falciparum in Children. Journal of Pharmaceutical Sciences, v. 108, n. 3, p. 1177-1188, MAR 2019. (16/18384-8, 14/16008-3)

MANCUSO, I, R.; FOGLIO, M. A.; SAAD, S. T. OLALLA. Artemisinin-type drugs for the treatment of hematological malignancies. Cancer Chemotherapy and Pharmacology, v. 87, n. 1, NOV 2020. (17/21801-2, 16/18384-8, 14/16008-3)

VOLPE-ZANUTTO, FABIANA; FERREIRA, LETICIA TIBURCIO; PERMANA, ANDI DIAN; KIRKBY, MELISSA; PAREDES, ALEJANDRO J.; VORA, LALITKUMAR K.; BONFANTI, AMANDA P.; CHARLIE-SILVA, IVES; RAPOSO, CATARINA; FIGUEIREDO, MARIANA C.; et al. Artemether and lumefantrine dissolving microneedle patches with improved pharmacokinetic performance and antimalarial efficacy in mice infected with Plasmodium yoelii. JOURNAL OF CONTROLLED RELEASE, v. 333, p. 298-315, MAY 10 2021. (19/02171-3, 16/18384-8, 14/16008-3, 17/18611-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ZANUTTO, Fabiana Volpe. Development of patches containing the association of Artemether - Lumefantrine for the treatment of malaria caused by Plasmodium falciparum. 2019. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.