The popularly known stingless bees can produce propolis or geopropolis. Propolis is made by bees from plant exudates, resins, balsams, pollen, wax, and bee gland secretions, showing several pharmacological properties. Regarding geopropolis, some species of Meliponinae add soil to its composition. In recent decades, several studies have been published on propolis and immunity, but there are few works found on geopropolis and its immunomodulatory action. In a recent work from our group, we evaluated its chemical composition and the inhibitory action on human laryngeal epidermoid carcinoma (HEp-2) cells. Considering the resistance of tumor cells to various chemotherapeutic agents, we investigated the association of geopropolis with conventional antitumor drugs (carboplatin, methotrexate and doxorubicin), in order to advance in the understanding of the main mechanisms by which this natural product would act on tumor cells, favoring or not the action of drugs. Since the combination of chemotherapeutic agents and geopropolis may be an effective anti-tumor therapy, this study aims to investigate the cytotoxic and immunomodulatory action of these associations on human monocytes, in order to assess a possible damage to normal cells of tumor-bearing individuals.
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