Chemical study of Fridericia speciosa Mart. (Bignoniaceae) and evaluation of lipoxygenase inhibitory activity and cytotoxicity

• Grant number: 15/04999-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2015
• End date: December 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Patricia Mendonça Pauletti
• Grantee: Reinaldo Rodrigues Milani
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

Fridericia speciosa belongs to the family Bignoniaceae, which consists of 120 genera and 800 species of shrubs, trees and vines. The species of this taxon are distributed in tropical regions around the world, being of frequent occurrence in the Americas. The searches in PubMed, Web of Science and SciFinder database showed no articles about F. speciosa. Thus, the aims of this research project are to carry out the chemical study of the leaves ethanol extract of F. speciosa with potential use as an inhibitor of the enzyme lipoxygenase (LOX), which shown activity against LOX, evaluate the cytotoxic properties, and contribute to human resource formation in Franca region.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MILANI, REINALDO R.; ALVES, OSVAINE J. A.; BERTANHA, CAMILA S.; GIMENEZ, VALERIA M. M.; SQUARISI, IARA S.; NICOLELLA, HELOIZA D.; PAGOTTI, MARIANA C.; TAVARES, DENISE C.; E SILVA, MARCIO L. A.; CUNHA, WILSON R.; et al. ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES. Química Nova, v. 43, n. 10, p. 1404-1407, DEC 2020. (15/04999-8, 16/10313-4, 13/09280-6, 17/24860-0)