Trinuclear ruthenium carboxylates with functional ligands CO, NO and intercalators: chemical study and interactions with biomolecules target

• Grant number: 14/25561-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): July 01, 2015
• Effective date (End): April 30, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Sofia Nikolaou
• Grantee: Camila Fontes Neves da Silva
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 17/15202-9 - Photochemical research and systematic in vitro study of the interaction mechanisms in novel trinuclear ruthenium complexes with DNA using different techniques, BE.EP.DR

Abstract

This project aims to contribute significantly to the study of trinuclear ruthenium carboxylate focusing on bioinorganic area. Thus, it is planned to develop a new series of complexes with ligands intercalators of the type [Ru3O(OAc)5(py)2(L)](PF6), where py = pyridine, and L = 1,10-phenanthroline (1) , dppz (2) CH3 dppz (3) Cl-dppz (4), NO2 dppz (5). The complexes are synthesized according to the synthetic routes described in the literature and adaptations will be characterized using the techniques of UV-visible spectroscopy, IR, 1H and 13C NMR, elemental analysis, mass spectroscopy and cyclic voltammetry. The interaction between the new complexes with biomolecules such as calf thymus DNA and human serum albumin (HSA) by means of spectroscopic UV-visible and/or luminescence will be investigated. In addition to the synthesis and characterization of new complexes will be held kinetic and photochemical studies to investigate the CO and NO release mechanisms of the complex [Ru3O (OAc)6(4-acpy)2(CO)](1a), [Ru3O(OAc)6(4-tbpy) 2(CO)](2a), [Ru3O(OAc)6(4-acpy)2(NO)PF6(3a), [Ru3O(OAc)6(4-tbpy)2(NO)]PF6(4a). (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NEVES DA SILVA, CAMILA FONTES; HAUCH CHRISPIM, PEDRO BRANCO; POSSATO, BRUNA; PORTAPILLA, GISELE BULHOES; ROHRABAUGH, JR., THOMAS N.; BARBOSA RAMOS, LOYANNE CARLA; DA SILVA, ROBERTO SANTANA; DE ALBUQUERQUE, SERGIO; TURRO, CLAUDIA; NIKOLAOU, SOFIA. Anticancer and antitrypanosomal activities of trinuclear ruthenium compounds with orthometalated phenazine ligands. DALTON TRANSACTIONS, v. 49, n. 45, p. 16440-16452, DEC 7 2020. (18/18060-3, 14/25561-8, 17/15202-9)

NEVES DA SILVA, CAMILA FONTES; POSSATO, BRUNA; FRANCO, LILIAN PEREIRA; BARBOSA RAMOS, LOYANNE CARLA; NIKOLAOU, SOFIA. The role of ancillary ligand substituents in the biological activity of triruthenium-NO complexes. Journal of Inorganic Biochemistry, v. 186, p. 197-205, SEP 2018. (14/25561-8, 15/20302-7)

SILVA, CAMILA F. N.; BARBOSA RAMOS, LOYANNE CARLA; ROHRABAUGH, THOMAS N.; VANDEVORD, JESSICA M.; DA SILVA, ROBERTO SANTANA; TURRO, CLAUDIA; NIKOLAOU, SOFIA. Exploring the structure of a ruthenium acetate cluster for biological purposes. Inorganic Chemistry Communications, v. 114, APR 2020. (17/15202-9, 14/25561-8, 18/18060-3)

DA SILVA, CAMILA F. N.; AL-AFYOUNI, MALIK; XUE, CONGCONG; FERREIRA, FREDERICO HENRIQUE DO C.; COSTA, LUIZ ANTONIO S.; TURRO, CLAUDIA; NIKOLAOU, SOFIA. Syntheses and electronic, electrochemical, and theoretical studies of a series of mu-oxo-triruthenium carboxylates bearing orthometalated phenazines. DALTON TRANSACTIONS, v. 49, n. 5, p. 1688-1698, FEB 7 2020. (17/15202-9, 14/25561-8, 18/18060-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Camila Fontes Neves da. \Trinuclear ruthenium carboxylates with intercalating ligands: chemical and interaction studies with target biomolecules\. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (PCARP/BC) Ribeirão Preto.