High blood lead levels in preschool children: investigation of metal concentrations in possible exposure sources

• Grant number: 15/01395-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2015
• End date: July 31, 2016
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Kelly Polido Kaneshiro Olympio
• Grantee: Júlia Prestes da Rocha Silva
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Lead (Pb) is widely known to be a ubiquitous metal and highly toxic to human health. In Brazil, there are few data on the extention of Pb contamination in the general population, especially in the most vulnerable population composed by preschool children. In a previous and funded by FAPESP study (Process 2011/13076-0, 2011/23272-0 and 2012/21840-4), venous blood was collected of 2,397 children attending 50 day care centers (DCCs), in São Paulo. These blood samples were analyzed and the results were processed. The results showed a geometric mean of blood lead levels of 2.16 ug/dL (95% CI: 2.10 to 2.22 ug/dL) and 97.5 percentile of 13.9 ug/dL (95% CI: 10.0 to 17.3 ug/dL). These results represent almost twice the value of the geometric mean found in the United States and almost three times the reference value indicated by the Centers for Disease Control and Prevention (97.5 percentile = 5 ug/dL). This way, the present study is a continuation of the above research and it aims to analyze which are the main sources of lead exposure for children, considering the home and CEIs settings through direct analysis of by X-ray fluorescence. These results will be compared between two groups: High exposure (e 13.9 ug/dL, 97.5 percentile found in the previous research) and Low exposure (<5 ug/dL). Descriptive statistics, correlation tests and multiple regression analysis will be applied to the data.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEROUX, ISABELLE NOGUEIRA; SACONE DA SILVA FERREIRA, ANA PAULA; DA ROCHA SILVA, JULIA PRESTES; BEZERRA, FLAVIO FERREIRA; DA SILVA, FABIO FERREIRA; SALLES, FERNANDA JUNQUEIRA; LUZ, MACIEL SANTOS; DE ASSUNCAO, NILSON ANTONIO; ALVES CARDOSO, MARIA REGINA; KANESHIRO OLYMPIO, KELLY POLIDO. Lead exposure from households and school settings: influence of diet on blood lead levels. Environmental Science and Pollution Research, v. 25, n. 31, SI, p. 31535-31542, NOV 2018. (14/20945-2, 12/21840-4, 14/22118-6, 15/01395-4, 11/23272-0)

LEROUX, ISABELLE NOGUEIRA; DA SILVA FERREIRA, ANA PAULA SACONE; PANIZ, FERNANDA POLLO; PEDRON, TATIANA; SALLES, FERNANDA JUNQUEIRA; DA SILVA, FABIO FERREIRA; MALTEZ, HELOISA FRANCA; BATISTA, BRUNO LEMOS; KANESHIRO OLYMPIO, KELLY POLIDO. Lead, Cadmium, and Arsenic Bioaccessibility of 24 h Duplicate Diet Ingested by Preschool Children Attending Day Care Centers in Brazil. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 15, n. 8, AUG 2018. (16/10060-9, 12/21840-4, 14/05151-0, 15/01395-4, 11/23272-0, 14/20945-2, 11/13076-0)

LEROUX, ISABELLE NOGUEIRA; SACONE DA SILVA FERREIRA, ANA PAULA; DA ROCHA SILVA, JULIA PRESTES; BEZERRA, FLAVIO FERREIRA; DA SILVA, FABIO FERREIRA; SALLES, FERNANDA JUNQUEIRA; LUZ, MACIEL SANTOS; DE ASSUNCAO, NILSON ANTONIO; ALVES CARDOSO, MARIA REGINA; KANESHIRO OLYMPIO, KELLY POLIDO. Lead exposure from households and school settings: influence of diet on blood lead levels. Environmental Science and Pollution Research, v. 25, n. 31, p. 8-pg., 2018-11-01. (11/23272-0, 14/20945-2, 12/21840-4, 15/01395-4, 14/22118-6)

DA ROCHA SILVA, JULIA PRESTES; SALLES, FERNANDA JUNQUEIRA; LEROUX, ISABELLE NOGUEIRA; SACONE DA SILVA FERREIRA, ANA PAULA; DA SILVA, AGNES SOARES; ASSUNCAO, NILSON ANTONIO; NARDOCCI, ADELAIDE CASSIA; SAYURI SATO, ANA PAULA; BARBOSA, JR., FERNANDO; ALVES CARDOSO, MARIA REGINA; et al. High blood lead levels are associated with lead concentrations in households and day care centers attended by Brazilian preschool children. Environmental Pollution, v. 239, p. 681-688, AUG 2018. (15/01395-4, 14/20945-2, 11/23272-0, 12/21840-4)