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Neural mechanisms involved in the generation of arterial hypertension in female rats submitted to chronic intermittent hypoxia

Grant number: 15/06550-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2015
Effective date (End): May 31, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Benedito Honorio Machado
Grantee:George Miguel Perbone Robuste Souza
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/06077-5 - Changes in the neural networks involved with the generation and control of sympathetic and respiratory activities in different experimental models of hypoxia, AP.TEM


Chronic intermittent hypoxia (CIH) promotes changes in the respiratory- sympathetic coupling and hypertension in male rats. After CIH, male rats present increased sympathetic activity during the late phase of expiration, which may contribute, at least in part, to the development of hypertension. Similarly, recent studies from our laboratory have shown that female rats submitted to CIH develop high blood pressure and changes in the respiratory-sympathetic coupling, different from the pattern observed in males, since CIH-female rats have increased sympathetic activity during inspiration. These observations suggest that although both male and female rats develop hypertension after CIH, the neural mechanisms underlying the changes in sympathetic respiratory coupling are different. Considering this information, the hypothesis of the present project is: female rats submitted to CIH have increased sympathetic activity related to inspiration, suggesting that pre-sympathetic and respiratory neurons present changes in their activity, becoming more excitable after CIH. To test this hypothesis, we will study the activity of pre-sympathetic and respiratory neurons in the ventral medulla of juvenile female rats submitted to CIH. For this, we will use the working heart brainstem preparation. With this study we can achieve important electrophysiological information for a better understanding about the respiratory modulation of neurons involved in the generation of sympathetic activity and its implications in the pathogenesis of hypertension in females. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUZA, GEORGE M. P. R.; BARNETT, WILLIAM H.; AMORIM, MATEUS R.; LIMA-SILVEIRA, LUDMILA; MORAES, DAVI J. A.; MOLKOV, I, YAROSLAV; MACHADO, BENEDITO H. Pre- and post-inspiratory neurons change their firing properties in female rats exposed to chronic intermittent hypoxia. Neuroscience, v. 406, p. 467-486, MAY 15 2019. Web of Science Citations: 0.
SOUZA, GEORGE MIGUEL P. R.; AMORIM, MATEUS R.; MORAES, DAVI J. A.; MACHADO, BENEDITO H. Sex differences in the respiratory-sympathetic coupling in rats exposed to chronic intermittent hypoxia. Respiratory Physiology & Neurobiology, v. 256, n. SI, p. 109-118, OCT 2018. Web of Science Citations: 3.

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