Effects of the use of immunosuppression with rapamycin or cyclosporine associated with mycophenolate mofetil on islet allografts in rat stomach

• Grant number: 14/18202-1
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2015
• End date: March 09, 2016
• Field of knowledge: Health Sciences - Medicine - Surgery
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Eleazar Chaib
• Grantee: Alberto Luiz Monteiro Meyer
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The scarcity of islets is an obstacle to the widespread use of islets for allotransplantation. Besides many pancreas donor are not suitable for extraction of islets, because they do not meet the selection criteria and the fact of improper manipulation of islets, only a small number of islet transplants can be performed. It is therefore essential to develop an unlimited source of cells capable of secreting insulin. The objective of this study is to compare rapamycin and cyclosporine immunosuppressive effects on islet allograft in rats. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANTUNES DE MESQUITA, GUSTAVO HELUANI; JARDIM, YURI JUSTI; IUAMOTO, LEANDRO RYUCHI; SUGUITA, FABIO YUJI; ESSU, FELIPE FUTEMA; OLIVEIRA, LUCAS TORRES; MEYER, ALBERTO; CRESCENZI, ALESSANDRA; ROCHA-SANTOS, VINICIUS; GALVAO, FLAVIO H. F.; et al. Gastric fundus submucosa as a site for islets transplantation: An experimental study. ANNALS OF MEDICINE AND SURGERY, v. 28, p. 1-5, APR 2018. (14/18202-1)