Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gastric fundus submucosa as a site for islets transplantation: An experimental study

Full text
Author(s):
Show less -
Antunes de Mesquita, Gustavo Heluani [1] ; Jardim, Yuri Justi [1] ; Iuamoto, Leandro Ryuchi [1] ; Suguita, Fabio Yuji [1] ; Essu, Felipe Futema [1] ; Oliveira, Lucas Torres [1] ; Meyer, Alberto [2, 3] ; Crescenzi, Alessandra [2] ; Rocha-Santos, Vinicius [2] ; Galvao, Flavio H. F. [2] ; Andraus, Wellington [3] ; Chaib, Eleazar [2] ; Carneiro D'Albuquerque, Luiz Augusto [2, 3]
Total Authors: 13
Affiliation:
[1] Univ Sao Paulo, Fac Med FMUSP, Dr Nicolau de Souza Queiros St, 406, Apartment 92, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Div Transplante Figado, LIM 37, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Gastroenterol, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ANNALS OF MEDICINE AND SURGERY; v. 28, p. 1-5, APR 2018.
Web of Science Citations: 0
Abstract

Background: Islets of Langerhans transplantation is a promising alternative for glycemic control in patients with type 1 diabetes. The graft site is a factor that has large impact on the functioning of this transplant, and the stomach appears to be a promising location. Our objective is to describe a new experimental model for the grafting of Islets of Langerhans in rat stomachs. Methodology: Islets of Langerhans were extracted from 45 isogenic male rats of the Lewis lineage and transplanted into 9 isogenic rats of the Wistar lineage; 5 in the gastric body submucosa, and 4 in the gastric fundus submucosa. Normoglycemia was defined as two successive measurements of < 250 mg/dL. No immunosuppression was used. The two groups glycemia control improvement were compared with t-student test. Results: The results obtained following the transplantation of the islets in 9 rats showed between 995 and 2310 islets transplanted (mean of 1367). The rats from the gastric submucosa group had a better glycemic level improvement, with a confidence equal to 83.94%. Conclusion: Islets graft into the gastric fundus submucosa is a viable model with potential for adequate glycemic control. This model gives potential for new perspectives and future studies in this area. (AU)

FAPESP's process: 14/18202-1 - Effects of the use of immunosuppression with rapamycin or cyclosporine associated with mycophenolate mofetil on islet allografts in rat stomach
Grantee:Alberto Luiz Monteiro Meyer
Support type: Scholarships in Brazil - Post-Doctorate