| Full text | |
| Author(s): Show less - |
Antunes de Mesquita, Gustavo Heluani
[1]
;
Jardim, Yuri Justi
[1]
;
Iuamoto, Leandro Ryuchi
[1]
;
Suguita, Fabio Yuji
[1]
;
Essu, Felipe Futema
[1]
;
Oliveira, Lucas Torres
[1]
;
Meyer, Alberto
[2, 3]
;
Crescenzi, Alessandra
[2]
;
Rocha-Santos, Vinicius
[2]
;
Galvao, Flavio H. F.
[2]
;
Andraus, Wellington
[3]
;
Chaib, Eleazar
[2]
;
Carneiro D'Albuquerque, Luiz Augusto
[2, 3]
Total Authors: 13
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med FMUSP, Dr Nicolau de Souza Queiros St, 406, Apartment 92, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Div Transplante Figado, LIM 37, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Gastroenterol, Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | ANNALS OF MEDICINE AND SURGERY; v. 28, p. 1-5, APR 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: Islets of Langerhans transplantation is a promising alternative for glycemic control in patients with type 1 diabetes. The graft site is a factor that has large impact on the functioning of this transplant, and the stomach appears to be a promising location. Our objective is to describe a new experimental model for the grafting of Islets of Langerhans in rat stomachs. Methodology: Islets of Langerhans were extracted from 45 isogenic male rats of the Lewis lineage and transplanted into 9 isogenic rats of the Wistar lineage; 5 in the gastric body submucosa, and 4 in the gastric fundus submucosa. Normoglycemia was defined as two successive measurements of < 250 mg/dL. No immunosuppression was used. The two groups glycemia control improvement were compared with t-student test. Results: The results obtained following the transplantation of the islets in 9 rats showed between 995 and 2310 islets transplanted (mean of 1367). The rats from the gastric submucosa group had a better glycemic level improvement, with a confidence equal to 83.94%. Conclusion: Islets graft into the gastric fundus submucosa is a viable model with potential for adequate glycemic control. This model gives potential for new perspectives and future studies in this area. (AU) | |
| FAPESP's process: | 14/18202-1 - Effects of the use of immunosuppression with rapamycin or cyclosporine associated with mycophenolate mofetil on islet allografts in rat stomach |
| Grantee: | Alberto Luiz Monteiro Meyer |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |