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Evauation of DNA damage in medical residents occupationally exposed to waste anesthetic gases

Grant number: 15/06420-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2015
Effective date (End): December 31, 2015
Field of knowledge:Biological Sciences - Genetics - Mutagenesis
Principal Investigator:Mariana Gobbo Braz
Grantee:Nayara Micarelli de Arruda
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


The genetic material is exposed to several toxic agents, which can induce damage, causing alterations in the genome. Reports have shown that chronic exposure to inhalational anesthetics may have negative impact on health. Therefore, the evaluation of the effect of exposure to waste anesthetic gases on newly exposed professionals who work in operating rooms without still adequate exhaust system and air exchange is relevant. In this study, we will assess DNA damage in medical residents exposed to waste anesthetic gases for three years (at the end of residency). Thus, the study will be conducted in 40 medical residents, allocated into two groups according to occupational exposure or not (control) to waste anesthetic gases. Blood samples will be collected and coded, and lymphocytes will be isolated for evaluation of DNA damage by the comet assay. Our data will help to better understand the impact of occupational exposure to inhalational anesthetics on the genome of young professionals.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BRAZ, MARIANA G.; CARVALHO, LORENA I. M.; CHEN, CHUNG-YEN O.; BLUMBERG, JEFFREY B.; SOUZA, KATINA M.; ARRUDA, NAYARA M.; FILHO, DANIEL A. A.; RESENDE, LUDIMILA O.; FARIA, RENATA T. B. G.; CANARIO, CLARA D'A; DE CARVALHO, LIDIA R.; CORREA, CAMILA R.; BRAZ, JOSE REINALDO C.; BRAZ, LEANDRO G. High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross-sectional study. INDOOR AIR, v. 30, n. 3, p. 512-520, MAY 2020. Web of Science Citations: 0.

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