The effects of Parkinson's disease on electroencephalography recordings during free walking and obstacle crossing

• Grant number: 14/22308-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2015
• End date: July 29, 2019
• Field of knowledge: Health Sciences - Physical Education
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Lilian Teresa Bucken Gobbi
• Grantee: Rodrigo Vitório
• Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil
• Associated scholarship(s): 16/00518-8 - Effect of ageing and Parkinson's disease on brain cortical activity during walking: association with cognition and visual sampling, BE.EP.PD

Abstract

Recent studies suggest that the cerebral cortex is involved in two distinct pathways for the control of human locomotion: the first acts in the control of steady-state locomotion and the second one acts in the planning and modulation of walking on uneven terrain. As patients with Parkinson's disease (PD) have impairments in both walking conditions, one might suggest that deficits in the cortical activity contribute to walking impairments in patients with PD. Thus, it becomes evident the need to investigate the activation of the cerebral cortex during walking in patients with PD. The aim of the current research project is to investigate the complexity of electroencephalography signals and the functional connectivity between different cortical regions in patients with PD and healthy individuals during free walking and obstacle avoidance. Participants will be invited to walk at their preferred speed on a 10 m long walkway in two experimental conditions: free walking and obstacle crossing. Dependent variables will include spatiotemporal measures of gait (GAITRite®) and measures of the complexity of electroencephalography rhythms (Wavelet Packet Entropy) and functional connectivity (Partial Directed Coherence) between cortical regions (prefrontal cortex, right and left sensorimotor cortex, central region, and occipital cortex). The current research project hopes to contribute to the understanding of the neural substrate of gait impairments in PD and, as a consequence, to guide the development of new procedures for treatment and rehabilitation. (AU)

Scientific publications

(19)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ORCIOLI-SILVA, DIEGO; VITORIO, RODRIGO; NOBREGA-SOUSA, PRISCILA; BERETTA, VICTOR SPIANDOR; DA CONCEICAO, NUBIA RIBEIRO; OLIVEIRA, ANDERSON SOUZA; PEREIRA, MARCELO PINTO; BUCKEN GOBBI, LILIAN TERESA. Cortical Activity Underlying Gait Improvements Achieved With Dopaminergic Medication During Usual Walking and Obstacle Avoidance in Parkinson Disease. NEUROREHABILITATION AND NEURAL REPAIR, MAR 2021. (16/21499-1, 17/19845-1, 14/22308-0)

NOBREGA-SOUSA, PRISCILA; GOBBI, LILIAN TERESA BUCKEN; ORCIOLI-SILVA, DIEGO; DA CONCEICAO, NUBIA RIBEIRO; BERETTA, VICTOR SPIANDOR; VITORIO, RODRIGO. Prefrontal Cortex Activity During Walking: Effects of Aging and Associations With Gait and Executive Function. NEUROREHABILITATION AND NEURAL REPAIR, AUG 2020. (14/22308-0, 16/21499-1)

CONCEICAO, NUBIA RIBEIRO; GOBBI, LILIAN TERESA BUCKEN; NOBREGA-SOUSA, PRISCILA; ORCIOLI-SILVA, DIEGO; BERETTA, VICTOR SPIANDOR; LIRANI-SILVA, ELLEN; OKANO, ALEXANDRE HIDEKI; VITORIO, RODRIGO. Aerobic Exercise Combined With Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Parkinson Disease: Effects on Cortical Activity, Gait, and Cognition. NEUROREHABILITATION AND NEURAL REPAIR, MAY 2021. (14/22308-0, 16/21499-1)

ORCIOLI-SILVA, DIEGO; VITORIO, RODRIGO; NOBREGA-SOUSA, PRISCILA; DA CONCEICAO, NUBIA RIBEIRO; BERETTA, VICTOR SPIANDOR; LIRANI-SILVA, ELLEN; GOBBI, LILIAN TERESA BUCKEN. Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease. NEUROREHABILITATION AND NEURAL REPAIR, MAY 2020. (14/22308-0, 16/21499-1)

ZAMPIER, VINICIUS C.; VITORIO, RODRIGO; BERETTA, VICTOR S.; JAIMES, DIEGO A. R.; ORCIOLI-SILVA, DIEGO; SANTOS, PAULO C. R.; GOBBI, LILIAN T. B.. Gait bradykinesia and hypometria decrease as arm swing frequency and amplitude increase. Neuroscience Letters, v. 687, p. 248-252, NOV 20 2018. (16/00503-0, 15/22141-0, 14/22308-0)

ORCIOLI-SILVA, DIEGO; VITORIO, RODRIGO; LIRANI-SILVA, ELLEN; ROCHA SANTOS, PAULO CEZAR; BERETTA, VICTOR SPIANDOR; BUCKEN GOBBI, LILIAN TERESA. Objective measures of unobstructed walking and obstacle avoidance in Parkinson's disease subtypes. GAIT & POSTURE, v. 62, p. 405-408, MAY 2018. (10/07040-0, 14/22308-0, 13/27032-0)

BERETTA, VICTOR SPIANDOR; CONCEICAO, NUBIA RIBEIRO; NOBREGA-SOUSA, PRISCILA; ORCIOLI-SILVA, DIEGO; BRAZ FONSECA DANTAS, LUANA KARLA; BUCKEN GOBBI, LILIAN TERESA; VITORIO, RODRIGO. Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson's disease: a systematic review. JOURNAL OF NEUROENGINEERING AND REHABILITATION, v. 17, n. 1, JUN 15 2020. (14/22308-0, 16/21499-1, 18/07385-9)

VITORIO, RODRIGO; LIRANI-SILVA, ELLEN; ORCIOLI-SILVA, DIEGO; BERETTA, VICTOR SPIANDOR; OLIVEIRA, ANDERSON SOUZA; GOBBI, LILIAN TERESA BUCKEN. Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson's Disease. SENSORS, v. 23, n. 10, p. 13-pg., 2023-05-18. (17/19845-1, 14/22308-0)

ORCIOLI-SILVA, DIEGO; VITORIO, RODRIGO; NOBREGA-SOUSA, PRISCILA; DA CONCEICAO, NUBIA RIBEIRO; BERETTA, VICTOR SPIANDOR; LIRANI-SILVA, ELLEN; GOBBI, LILIAN TERESA BUCKEN. Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease. NEUROREHABILITATION AND NEURAL REPAIR, v. 34, n. 7, p. 11-pg., 2020-05-25. (16/21499-1, 14/22308-0)

BERETTA, VICTOR SPIANDOR; VITORIO, RODRIGO; NOBREGA-SOUSA, PRISCILA; CONCEICAO, NUBIA RIBEIRO; ORCIOLI-SILVA, DIEGO; PEREIRA, MARCELO PINTO; BUCKEN GOBBI, LILIAN TERESA. Effect of Different Intensities of Transcranial Direct Current Stimulation on Postural Response to External Perturbation in Patients With Parkinson's Disease. NEUROREHABILITATION AND NEURAL REPAIR, v. 34, n. 11, p. 11-pg., 2020-10-01. (18/07385-9, 16/21499-1, 14/22308-0)

NOBREGA-SOUSA, PRISCILA; GOBBI, LILIAN TERESA BUCKEN; ORCIOLI-SILVA, DIEGO; DA CONCEICAO, NUBIA RIBEIRO; BERETTA, VICTOR SPIANDOR; VITORIO, RODRIGO. Prefrontal Cortex Activity During Walking: Effects of Aging and Associations With Gait and Executive Function. NEUROREHABILITATION AND NEURAL REPAIR, v. 34, n. 10, p. 10-pg., 2020-08-31. (14/22308-0, 16/21499-1)

VITORIO, RODRIGO; STUART, SAMUEL; CHARVET, LEIGH E.; GODFREY, ALAN. Introducing the thematic series on transcranial direct current stimulation (tDCS) for motor rehabilitation: on the way to optimal clinical use. JOURNAL OF NEUROENGINEERING AND REHABILITATION, v. 16, p. 3-pg., 2019-03-04. (14/22308-0)

DA CONCEICAO, NUBIA RIBEIRO; DE SOUSA, PRISCILA NOBREGA; PEREIRA, MARCELO PINTO; BUCKEN GOBBI, LILIAN TERESA; VITORIO, RODRIGO. Utility of center of pressure measures during obstacle crossing in prediction of fall risk in people with Parkinson's disease. HUMAN MOVEMENT SCIENCE, v. 66, p. 1-8, AUG 2019. (14/22308-0, 10/07040-0)

STUART, SAMUEL; VITORIO, RODRIGO; MORRIS, ROSIE; MARTINI, DOUGLAS N.; FINO, PETER C.; MANCINI, MARTINA. Cortical activity during walking and balance tasks in older adults and in people with Parkinson's disease: A structured review. MATURITAS, v. 113, p. 53-72, JUL 2018. (14/22308-0)

BERETTA, VICTOR SPIANDOR; ORCIOLI-SILVA, DIEGO; CONCEICA, NUBIA RIBEIRO; NOBREGA-SOUSA, PRISCILA; PEREIRA, SOUSA A MARCELO PINTO; GOBBI, LILIAN TERESA BUCKEN; VITORIO, RODRIGO. tDCS application for postural control in Parkinson's disease: Effects are associated with baseline characteristics. PARKINSONISM & RELATED DISORDERS, v. 93, p. 62-65, DEC 2021. (14/22308-0, 18/07385-9, 16/21499-1)

NOBREGA-SOUSA, PRISCILA; ORCIOLI-SILVA, DIEGO; LIRANI-SILVA, ELLEN; BERETTA, VICTOR SPIANDOR; VITORIO, RODRIGO; BUCKEN GOBBI, LILIAN TERESA. Usual walking and obstacle avoidance are influenced by depressive and anxiety symptoms in patients with Parkinson's disease. Geriatrics & Gerontology International, v. 19, n. 9, JULY 2019. (14/22308-0, 10/07040-0)

ORCIOLI-SILVA, DIEGO; VITORIO, RODRIGO; NOBREGA-SOUSA, PRISCILA; BERETTA, VICTOR SPIANDOR; DA CONCEICAO, NUBIA RIBEIRO; OLIVEIRA, ANDERSON SOUZA; PEREIRA, MARCELO PINTO; BUCKEN GOBBI, LILIAN TERESA. Cortical Activity Underlying Gait Improvements Achieved With Dopaminergic Medication During Usual Walking and Obstacle Avoidance in Parkinson Disease. NEUROREHABILITATION AND NEURAL REPAIR, v. 35, n. 5, p. 13-pg., 2021-03-23. (16/21499-1, 17/19845-1, 14/22308-0)

ORCIOLI-SILVA, DIEGO; VITORIO, RODRIGO; BERETTA, VICTOR SPIANDOR; DA CONCEICAO, NUBIA RIBEIRO; NOBREGA-SOUSA, PRISCILA; OLIVEIRA, ANDERSON SOUZA; BUCKEN GOBBI, LILIAN TERESA. Is Cortical Activation During Walking Different Between Parkinson's Disease Motor Subtypes?. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v. 76, n. 4, p. 7-pg., 2021-04-01. (17/19845-1, 14/22308-0)

CONCEICAO, NUBIA RIBEIRO; GOBBI, LILIAN TERESA BUCKEN; NOBREGA-SOUSA, PRISCILA; ORCIOLI-SILVA, DIEGO; BERETTA, VICTOR SPIANDOR; LIRANI-SILVA, ELLEN; OKANO, ALEXANDRE HIDEKI; VITORIO, RODRIGO. Aerobic Exercise Combined With Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Parkinson Disease: Effects on Cortical Activity, Gait, and Cognition. NEUROREHABILITATION AND NEURAL REPAIR, v. 35, n. 8, p. 12-pg., 2021-05-28. (14/22308-0, 16/21499-1)