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Synthesis of antileishmanial and antiChagas agents for drug prototypal development

Grant number: 15/02820-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2015
Effective date (End): June 30, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Roberto Gomes de Souza Berlinck
Grantee:Siddavatam Nagendra
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated research grant:13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands, AP.BTA.TEM

Abstract

The post-doctoral workplan aims at the development of the syntheses of naturally-derived and -modified organic compounds, based in scaffolds which have been recently discovered, presenting promising antileishmanial and antitrypanosomal activities. The synthesis of such anti-parasitic compounds aims to obtain actives and new derivatives to be further evaluated against Leishmania and T. cruzi parasites, both in vitro and in vivo. The applicant will be responsible to develop and to improve synthetic methods aiming to obtain optimized compounds as anti-parasitic agents. The applicant will also interact with medicinal chemists aiming to optimize structures, investigate pharmacophore(s) and establish structure X bioactivity relationships. Moreover, the applicant will participate in a multi-disciplinary and investigative program with international researchers at both USA and UK, in order to integrate his/her capabilities and knowledge on organic synthesis and medicinal chemistry.

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