Relaxometric characterization of a new platform of Gd-complexes based on the use of Gd-AAZTA functionalized with an acid function

• Grant number: 15/16624-9
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: March 06, 2016
• End date: March 05, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Luiz Alberto Colnago
• Grantee: Flavio Vinicius Crizostomo Kock
• Supervisor: Silvio Aime
• Host Institution: Embrapa Instrumentação Agropecuária. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil
• Institution abroad: Università degli Studi di Torino (UNITO), Italy
• Associated to the scholarship: 12/23169-8 - In situ study of action of quitosan biopolymer in the decontamination of metals and herbicides in aqueous system by electrochemistry coupled to high and low field NMR, BP.DR

Abstract

The project deals the development of new Gd-based relaxation agents, taking account of the fine tuning of a number of parameters, namely improved sensitivity, very high stability in vivo, well-controlled excretion process and well-defined distribution pathway. The aim of the project will be to investigate the relaxometric behaviour of a series of new synthesized contrast agents based on the use of Gd-AAZTA functionalized with a short (C2 spaced) acid function (Gd-AAZTAC2COOH) which enables a further conjugation with lipophilic chains or multimeric species. The use of a short linker between the metal coordination cage and the functionalizing group should reduce the internal mobility of the paramagnetic core thus allowing the obtainment of high relaxivity systems. The contrast agents will be modified in order to address two important issues: i) the probes will be endowed by targeting capability through the conjugation to suitable vectors and ii) signal amplification (multimeric systems, nanosized carriers) will be provided in order to overcome the MRI low sensitivity threshold.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CRIZOSTOMO KOCK, FLAVIO VINICIUS; FORGACS, ATTILA; GUIDOLIN, NICOL; STEFANIA, RACHELE; VAGNER, ADRIENN; GIANOLIO, ELIANA; AIME, SILVIO; BARANYAI, ZSOLT. [Gd(AAZTA)](-) Derivatives with n-Alkyl Acid Side Chains Show Improved Properties for Their Application as MRI Contrast Agents{*}{*}. CHEMISTRY-A EUROPEAN JOURNAL, v. 27, n. 5, DEC 2020. (15/16624-9, 12/23169-8, 18/16040-5)

FLÁVIO V. C. KOCK; LUIZ A. COLNAGO. NMR Relaxometry Applied to Chemical Studies of Paramagnetic Metal Cation Complexes: Fundamentals and Applications. Journal of the Brazilian Chemical Society, v. 33, n. 6, p. 509-522, 2022-05-30. (12/23169-8, 19/13656-8, 18/16040-5, 21/12694-3, 15/16624-9)

CRIZOSTOMO KOCK, FLAVIO VINICIUS; FORGACS, ATTILA; GUIDOLIN, NICOL; STEFANIA, RACHELE; VAGNER, ADRIENN; GIANOLIO, ELIANA; AIME, SILVIO; BARANYAI, ZSOLT. [Gd(AAZTA)](-) Derivatives with n-Alkyl Acid Side Chains Show Improved Properties for Their Application as MRI Contrast Agents**. CHEMISTRY-A EUROPEAN JOURNAL, v. 27, n. 5, p. 11-pg., 2020-12-28. (15/16624-9, 12/23169-8, 18/16040-5)