The implant therapy have been a predictable alternative to replace partially or totally missing teeth. However, systemic disease such as diabetes mellitus (DM), may negatively influence the osseointegration. Changes in microtopography and the implant surface are two strategies used to promote better bone anchorage. Thus, taking into account the development of new implant surfaces with processes aimed at qualitative and quantitative improvement of osseointegration phenomenon, and on the other hand the healing deficiency of DM, which can be used as models of subjects with impaired bone repair. The aim of this in vivo study is to evaluate the biologic response of a new 4th generation implant surface, modified by the addition of nano-hydroxyapatite through histomorphometric analysis, micro computed tomography (micro CT) and gene expression in diabetic and non-diabetic rats. Mini implants (machined, treated surface with double acid attack and with the addition of nano-hydroxyapatite) will be installed in the tibias of healthy rats (n=36) and diabetic rats (n=36). The animals will be euthanized at 7 and 30 days. The right tibia will be removed and fixed for further analysis and three-dimensional histological processing and the left for evaluation of gene Expression. The results are expressed as mean ± standard deviation of the groups in each period, considering the animal as experimental unit. Pre-tests will be performed to assess the normality of the data. Based on the results, the appropriate statistical tests to analyze differences between groups will be selected in each period (7 and 30 days), and intra-group, in relation to different times. In all analyzes, will be considered p <0.05.
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