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Microtomographic evaluation of a new hydroxiapatite covered nanometric implant surface: an in vivo study in rats

Grant number: 16/13959-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2016
Effective date (End): October 31, 2017
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Sérgio Luís Scombatti de Souza
Grantee:Ana Carolina Taveira Bachur
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The implant therapy have been a predictable alternative to replace partially or totally missing teeth. Changes in microtopography and the implant surface are two strategies used to promote better bone anchorage. Thus, taking into account the development of new implant surfaces with processes aimed at qualitative and quantitative improvement of osseointegration phenomenon, the aim of this in vivo study is to evaluate the biologic response of a new 4th generation implant surface, modified by the addition of nano-hydroxyapatite through micro computed tomography (micro CT) analysis. Mini implants (machined, treated surface with double acid attack and with the addition of nano-hydroxyapatite) will be installed in the tibias of healthy rats (n=36). The animals will be euthanized at 7 and 30 days. The right tibia will be removed and fixed for further three-dimensional analysis. Tomographic Bone to Implant Contact (IS/TS, in %), Bone Volume Fraction (BV/TV, in %), Bone Surface/Bone Volume (BS/BV, in mm2/mm3), and Total Porosity (To.po, in %) will be measured. These parameters will evaluate the bone characteristics between the threads of the implants. The results are expressed as mean ± standard deviation of the groups in each period, considering the animal as experimental unit. Pre-tests will be performed to assess the normality of the data. Based on the results, the appropriate statistical tests to analyze differences between groups will be selected in each period (7 and 30 days), and intra-group, in relation to different times. In all analyzes, will be considered p <0.05. (AU)