Today, the implantology concentrates in studies that target and enable the more rapid osseointegration of surgical implants. The aim of this study will be to compare the bone neoformations into porous surface samples, made of different titanium (Ti) alloys. Also, we will correlate the structural properties of the different titanium alloys with the bone neoformations obtained in the porous samples. By means of powder metallurgy, 75 samples exhibiting dense core integrated to the porous surface, will be made and divided into five groups: a) group 1: control - commercially pure titanium; b) group 2: Ti-6Al-4V alloy (titanium-aluminium-vanadium); c) group 3: Ti-13Nb-13Zr alloy (titanium-niobium-zirconium); d) group 4: Ti-35Nb alloy (niobium); e) group 5: Ti-35Nb-7Zr-5Ta alloy (titanium-niobium-zirconium-tantalum). Five samples of each group will be submitted to chemical, morphological and mechanical characterization. In this study fifteen rabbits will be used to evaluate and to compare the bone neoformation obtained in the porous surface samples by means of histological and histomorphometric analyses and also by the use of fluorescent markers. Additionally, image analysis will be performed 3D, microtomography (¼CT) to verify the quantification bone inside the porous surface.Each rabbit will receive one sample of each group and the G1, G2, G3 samples will be inserted into the right tibiae and the G4, G5 samples in the left tibiae. Five rabbits, randomly selected, will be euthanized 2, 4 and 8 weeks after the surgery. The data will be evaluated by the ANOVA statistical test and if necessary a Tukey multiple comparison test of Tukey will be used(p <0.05). (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
DO PRADO, RENATA FALCHETE;
ESTEVES, GABRIELA CAMPOS;
DE SOUZA SANTOS, EVELYN LUZIA;
GRITI BUENO, DAIANE ACACIA;
ALVES CAIRO, CARLOS ALBERTO;
OLIVEIRA DE VASCONCELLOS, LUIS GUSTAVO;
SAGNORI, RENATA SILVEIRA;
PEREIRA TESSARIN, FERNANDA BASTOS;
OLIVEIRA, FELIPE EDUARDO;
DE OLIVEIRA, LUCIANE DIAS;
LIMA VILLACA-CARVALHO, MARIA FERNANDA;
RODRIGUES HENRIQUES, VINICIUS ANDRE;
CARVALHO, YASMIN RODARTE;
REIS DE VASCONCELLOS, LUANA MAROTTA.
In vitro and in vivo biological performance of porous Ti alloys prepared by powder metallurgy.
MAY 17 2018.
Web of Science Citations: 4.
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