In vivo comparison of biocompatibility of porous surface samples made with different titanium alloys

• Grant number: 12/20311-8
• Support Opportunities: Regular Research Grants
• Duration: May 01, 2013 - April 30, 2015
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Luana Marotta Reis de Vasconcellos
• Grantee: Luana Marotta Reis de Vasconcellos
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil
• Associated researchers: Carlos Alberto Alves Cairo ; Renata Falchete Do Prado ; Yasmin Rodarte Carvalho

Abstract

Today, the implantology concentrates in studies that target and enable the more rapid osseointegration of surgical implants. The aim of this study will be to compare the bone neoformations into porous surface samples, made of different titanium (Ti) alloys. Also, we will correlate the structural properties of the different titanium alloys with the bone neoformations obtained in the porous samples. By means of powder metallurgy, 75 samples exhibiting dense core integrated to the porous surface, will be made and divided into five groups: a) group 1: control - commercially pure titanium; b) group 2: Ti-6Al-4V alloy (titanium-aluminium-vanadium); c) group 3: Ti-13Nb-13Zr alloy (titanium-niobium-zirconium); d) group 4: Ti-35Nb alloy (niobium); e) group 5: Ti-35Nb-7Zr-5Ta alloy (titanium-niobium-zirconium-tantalum). Five samples of each group will be submitted to chemical, morphological and mechanical characterization. In this study fifteen rabbits will be used to evaluate and to compare the bone neoformation obtained in the porous surface samples by means of histological and histomorphometric analyses and also by the use of fluorescent markers. Additionally, image analysis will be performed 3D, microtomography (¼CT) to verify the quantification bone inside the porous surface.Each rabbit will receive one sample of each group and the G1, G2, G3 samples will be inserted into the right tibiae and the G4, G5 samples in the left tibiae. Five rabbits, randomly selected, will be euthanized 2, 4 and 8 weeks after the surgery. The data will be evaluated by the ANOVA statistical test and if necessary a Tukey multiple comparison test of Tukey will be used(p <0.05). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

REIS MELLO, DAPHNE DE CAMARGO; DE OLIVEIRA, JONATAS RAFAEL; ALVES CAIRO, CARLOS ALBERTO; DE BRITO RAMOS, LAIS SIEBRA; DA CRUZ VEGIAN, MARIANA RAQUEL; DE VASCONCELLOS, LUIS GUSTAVO OLIVEIRA; DE OLIVEIRA, FELIPE EDUARDO; DE OLIVEIRA, LUCIANE DIAS; REIS DE VASCONCELLOS, LUANA MAROTTA. Titanium alloys: in vitro biological analyzes on biofilm formation, biocompatibility, cell differentiation to induce bone formation, and immunological response. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 30, n. 9, SEP 2019. (15/01258-7, 12/20311-8)

DO PRADO, RENATA FALCHETE; ESTEVES, GABRIELA CAMPOS; DE SOUZA SANTOS, EVELYN LUZIA; GRITI BUENO, DAIANE ACACIA; ALVES CAIRO, CARLOS ALBERTO; OLIVEIRA DE VASCONCELLOS, LUIS GUSTAVO; SAGNORI, RENATA SILVEIRA; PEREIRA TESSARIN, FERNANDA BASTOS; OLIVEIRA, FELIPE EDUARDO; DE OLIVEIRA, LUCIANE DIAS; et al. In vitro and in vivo biological performance of porous Ti alloys prepared by powder metallurgy. PLoS One, v. 13, n. 5, MAY 17 2018. (12/20311-8, 11/23662-3, 11/15342-9, 12/13338-7, 12/13324-6, 12/22158-2)