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In vitro study of biocompatibility of porous titanium alloys samples for biomedical application

Grant number: 12/13338-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2013
Effective date (End): January 31, 2014
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Yasmin Rodarte Carvalho
Grantee:Fernanda Bastos Pereira Tessarin
Home Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil

Abstract

The materials used for the manufacturing of surgical implants need to be biocompatible and resistant to corrosion, and provide appropriate modulus of elasticity. Titanium (Ti) and its alloys are the most used materials for this purpose, since its elasticity can be controlled by making pores and by the material of which the implant is manufactured. The aim of this study is to evaluate the influence of different porous samples on the osteoblast activity. The samples will be manufactured by means of powder metallurgy, and they will be divided into five groups: a) group 1: control - commercially pure titanium; b) group 2: Ti-6Al-4V alloy (titanium-aluminium-vanadium); c) group 3: Ti-13Nb-13Zr alloy (titanium-niobium-zirconium); d) group 4: Ti-35Nb alloy (niobium); e) group 5: Ti-35Nb-7Zr-5Ta alloy (titanium-niobium-zirconium-tantalum). Osteogenic cells are obtained from the calvaria of newborn rats and are cultivated on 18 samples of each group and evaluated for adhesion, cell viability (cytotoxicity), total protein content, alkaline phosphatase activity, production of TGF-²1, TNF -± and IL-6 after 3, 7 and 14 days. The formation of nodules and quantification of mineralization will be reviewed after 14 days. The results will be analyzed statistically with a significance level of 5%.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DO PRADO, RENATA FALCHETE; ESTEVES, GABRIELA CAMPOS; DE SOUZA SANTOS, EVELYN LUZIA; GRITI BUENO, DAIANE ACACIA; ALVES CAIRO, CARLOS ALBERTO; OLIVEIRA DE VASCONCELLOS, LUIS GUSTAVO; SAGNORI, RENATA SILVEIRA; PEREIRA TESSARIN, FERNANDA BASTOS; OLIVEIRA, FELIPE EDUARDO; DE OLIVEIRA, LUCIANE DIAS; LIMA VILLACA-CARVALHO, MARIA FERNANDA; RODRIGUES HENRIQUES, VINICIUS ANDRE; CARVALHO, YASMIN RODARTE; REIS DE VASCONCELLOS, LUANA MAROTTA. In vitro and in vivo biological performance of porous Ti alloys prepared by powder metallurgy. PLoS One, v. 13, n. 5 MAY 17 2018. Web of Science Citations: 4.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.