Comparative in vivo study of bone ingrowth in porous titanium alloys samples processed via powder metallurgy

• Grant number: 12/22158-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2013
• End date: March 31, 2015
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Luana Marotta Reis de Vasconcellos
• Grantee: Daiane Acacia Griti Bueno
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil

Abstract

The surface topography and manufacturing material of surgical implant can influence the osseointegration process, due to its chemical and physical changes. The aim of this study will be to compare implants made from different alloys of titanium porous surface associated with dense core bone regeneration. . By means of powder metallurgy, 50 implants showing dense core integrated with a porous surface, which will be divided into 5 groups: a) group 1: control - commercially pure Ti, b) Group 2: alloy Ti-6Al-4V (titanium -aluminum-vanadium) c) group 3: alloy Ti-13Nb-13Zr (zirconium-niobium-titanium) d) group 4: alloy Ti-35Nb (niobium-titanium), e) group 5: alloy Ti -35Nb-7ZR-5Ta (titanium-zirconium-niobium-tantalum). This study will use ten rabbits to evaluate and compare bone regeneration by means of histology and histomorphometry. Each rabbit will receive an implant in each group, implants G1, G2, G3 are inserted into the right tibia and G4, G5 in the left tibia. Five rabbits, randomly selected, will be euthanized 2 and 4 weeks after surgery. The data will be evaluated by ANOVA and when required by the multiple comparison test of Tukey (p <0.05).(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DO PRADO, RENATA FALCHETE; ESTEVES, GABRIELA CAMPOS; DE SOUZA SANTOS, EVELYN LUZIA; GRITI BUENO, DAIANE ACACIA; ALVES CAIRO, CARLOS ALBERTO; OLIVEIRA DE VASCONCELLOS, LUIS GUSTAVO; SAGNORI, RENATA SILVEIRA; PEREIRA TESSARIN, FERNANDA BASTOS; OLIVEIRA, FELIPE EDUARDO; DE OLIVEIRA, LUCIANE DIAS; et al. In vitro and in vivo biological performance of porous Ti alloys prepared by powder metallurgy. PLoS One, v. 13, n. 5, MAY 17 2018. (12/20311-8, 11/23662-3, 11/15342-9, 12/13338-7, 12/13324-6, 12/22158-2)

DO PRADO, RENATA FALCHETE; EL ABRAS ANKHA, MILAGROS DEL VALLE; GRITI BUENO, DAIANE ACACIA; DE SOUZA SANTOS, EVELYN LUZIA; PEREIRA TINI, ITALO RIGOTTI; RAMOS, CAROLINA JUDICA; SPALDING, MARIANNE; OLIVEIRA DE VASCONCELLOS, LUIS GUSTAVO; REIS DE VASCONCELLOS, LUANA MAROTTA. CaP Coating and Low-Level Laser Therapy to Stimulate Early Bone Formation and Improve Fixation of Rough Threaded Implants. IMPLANT DENTISTRY, v. 27, n. 6, p. 660-666, DEC 2018. (12/22158-2, 11/17392-3)