Which metabolomics components influence the phytopathogenicity of Colletotrichum spp.?

• Grant number: 15/14114-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2015
• End date: February 29, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Mirelle Takaki
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated scholarship(s): 18/03679-8 - Use of statistical tools and molecular networking for the metabolomics analysis of Colletotrichum spp, BE.EP.DR

Abstract

Fungi belonging to the genus Colletotrichum, which cause anthracnosis in plants, constitute one of the main phytopatogens around the world and affect cultures of sweet pepper, guarana, strawberry, passion fruit, mango, onions, garlic, among others. Despite the damages on different vegetables species of high economic and nutricional value, there is no completely efficient plant treatment to avoid the infection and damages promoted by Colletotrichum spp. Fungi belonging to this genus produce secondary metabolites, which may constitute part of the virulence arsenal associated to the fungi pathogenicity. However, very few metabolites produced by phytotoxic Colletotrichum on different plant species have been isolated and identified. In different investigations, compounds have been detected in media produced from phytotoxic Colletotrichum spp., but could not be isolated and identified because are produced only in trace amounts. The present project aims to use a metabolomics approach to investigate the ensemble of Colletotrichum spp. metabolites when the fungi express phytopathogenicity and not, in order to verify if the production of particular secondary metabolites is associated or not to the virulence of phytopathogenic Colletotrichum spp.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TAKAKI, MIRELLE; FREIRE, VITOR F.; NICACIO, KAREN J.; BERTONHA, ARIANE F.; NAGASHIMA, NOZOMU; SARPONG, RICHMOND; PADULA, VINICIUS; FERREIRA, ANTONIO G.; BERLINCK, ROBERTO G. S.. Metabolomics Reveals Minor Tambjamines in a Marine Invertebrate Food Chain. Journal of Natural Products, v. 84, n. 3, SI, p. 790-796, MAR 26 2021. (19/17721-9, 15/14114-3, 15/01017-0)

TAKAKI, MIRELLE; WILLIAMS, DAVID E.; FREIRE, VITOR F.; SARTORI, SERGIO B.; LIRA, SIMONE P.; BIZARRIA JR, RODOLFO; RODRIGUES, ANDRE; DA COSTA, DANIELLE R. GONCALVES; AMORIM, MARCELO R. .; FERREIRA, ANTONIO G.; et al. Metabolomics Reveals a 26-Membered Macrolactone Produced by Endophytic Colletotrichum spp. from Alcatrazes Island, Brazil. ORGANIC LETTERS, v. N/A, p. 5-pg., 2022-12-15. (20/01229-5, 13/50228-8, 18/03679-8, 15/14114-3, 19/17721-9)

BERLINCK, ROBERTO G. S.; BERTONHA, ARIANE F.; TAKAKI, MIRELLE; RODRIGUEZ, JULIE P. G.. The chemistry and biology of guanidine natural products. NATURAL PRODUCT REPORTS, v. 34, n. 11, p. 1264-1301, NOV 1 2017. (15/14114-3)

TAKAKI, MIRELLE; FREIRE, VITOR F.; NICACIO, KAREN J.; BERTONHA, ARIANE F.; NAGASHIMA, NOZOMU; SARPONG, RICHMOND; PADULA, VINICIUS; FERREIRA, ANTONIO G.; BERLINCK, ROBERTO G. S.. Metabolomics Reveals Minor Tambjamines in a Marine Invertebrate Food Chain. Journal of Natural Products, v. 84, n. 3, p. 7-pg., 2021-03-26. (19/17721-9, 15/01017-0, 15/14114-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

TAKAKI, Mirelle. Metabolomic study of fungi of the genus Colletotrichum and tambjamines- producing marine organisms. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC/BT) São Carlos.