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Mechanism and biological role of carnosine and carnosine derivatives

Grant number: 15/01681-7
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2015
Effective date (End): July 31, 2019
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Marisa Helena Gennari de Medeiros
Grantee:Adauto Luis Lorenzini Pessoa
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID

Abstract

An important goal of the CEPID-Redoxome project is to understand how redox-active intermediate reacts with specific biomolecules and the resulting effects, essential for designing biomarkers and antioxidants. Our group is studying the mechanisms of formation, detoxification and reaction with biomolecules of endogenous and exogenous aldehydes. Recently, the reaction of carnosine with acrolein was investigated by our group in an effort to assess its possible biological role. One stable adduct was isolated by reverse-phase HPLC and characterized on the basis of extensive spectroscopic measurements. This project aims to continue these studies investigating the role of carnosine in reactive aldehydes detoxification mechanisms and as singlet oxygen suppressor. This study is justified considering studies that indicate the ability of carnosine to reduce damage caused by ischemia/reperfusion in brain, liver, kidney and testis of animals and a possible therapeutic use of carnosine in conditions where the production of reactive aldehydes and reactive species oxygen are increased as in the case of individuals with ALDH2 deficiency and redox stress produced by cardiac ischemia. (AU)

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