Possible association of intramuscle macrophage content and insulin resistance in mice fed a high fat diet and exercise effects

• Grant number: 15/09144-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2015
• End date: June 30, 2016
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Helena Coutinho Franco de Oliveira
• Grantee: Jefferson Ferreira Simoura
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Considering that 1) muscle lipid accumulation and inflammation are key events in determining insulin resistance (IR), 2) exercise induces improvements in IR, and 3) hypercholesterolemic LDL receptor knockout (LDLr-/-) mice show no IR improvements after exercise training (unpublished data from our lab), we will investigate the exercise response of high fat diet fed wild type and LDLr-/- mice regarding: 1) muscle lipid content, 2) macrophage content and phenotype and 3) insulin signaling efficiency. (AU)