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Possible association of intramuscle macrophage content and insulin resistance in mice fed a high fat diet and exercise effects

Grant number: 15/09144-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2015
Effective date (End): June 30, 2016
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Helena Coutinho Franco de Oliveira
Grantee:Jefferson Ferreira Simoura
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Considering that 1) muscle lipid accumulation and inflammation are key events in determining insulin resistance (IR), 2) exercise induces improvements in IR, and 3) hypercholesterolemic LDL receptor knockout (LDLr-/-) mice show no IR improvements after exercise training (unpublished data from our lab), we will investigate the exercise response of high fat diet fed wild type and LDLr-/- mice regarding: 1) muscle lipid content, 2) macrophage content and phenotype and 3) insulin signaling efficiency. (AU)

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