Use of drugs containing nanocarriers with photosensitizers and/or other active compounds applied to cell therapy and treatment of central nervous system disorders

• Grant number: 15/18684-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: October 01, 2015
• End date: September 30, 2017
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Antonio Claudio Tedesco
• Grantee: Leonardo Barcelos de Paula
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 13/50181-1 - Use of drugs containing nanocarriers with photosensitizers and/or other active compounds applied to cell therapy and treatment of central nervous system disorders, AP.TEM

Abstract

It is estimated that approximately 1.5 billion people worldwide suffer with some kind of disorder of the central nervous system (CNS). Therefore, there is a high demand for effective treatments. Due to an increase in the number of elderly in the world population, if there is an increase or improvement of existing treatments, the number of people with diseases of the CNS will be approximately 1.9 billion by 2020. Among the major CNS diseases are solid tumors, cerebrovascular accident (CVA) and vasospasm of cerebral arteries. Among the tumors that affect the CNS, glioma is the most aggressive and frequent accounting for 50% of all tumors with survival less than one year. Other serious problems are called cerebrovascular accident (CVA), which is the second leading cause of death in Brazil and vasospasm of cerebral arteries, resulting from subarachnoid hemorrhage. All currently existing treatments for brain affections reported here are not very effective, resulting in a large number of patients with serious neurological damage or death. Therefore, the need to develop a more effective therapy. This project is divided into 5 sub-projects, three related to glioma, one related to stroke and another related to vasospasm of cerebral arteries. Thus, the studies proposed in this project seem very relevant, since the use of new technologies, on a theme already explored, but with little success, seems to be the key to the discovery of new therapeutic strategies. Therefore, the common guideline that unites all proposals is the combination of Nanotechnology, Fotoprocesso and Cell Therapy for the treatment of CNS diseases.

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JAYME, CRISTIANO CERON; REZENDE, NAYARA; FERNANDES, DANIELA S. .; PAULA, LEONARDO B. DE; DE CASTRO, BARBARA GIMENES; TAKAHASHI, LUANDRA APARECIDA U. .; TEDESCO, ANTONIO CLAUDIO. Target selectivity of cholesterol-phosphatidylcholine liposome loaded with phthalocyanine for breast cancer diagnosis and treatment by photodynamic therapy. Photodiagnosis and Photodynamic Therapy, v. 39, p. 6-pg., 2022-07-25. (18/24004-9, 21/02207-8, 18/10237-1, 15/18684-9, 13/50181-1)

JAYME, CRISTIANO CERON; DE PAULA, LEONARDO BARCELOS; REZENDE, NAYARA; CALORI, ITALO RODRIGO; FRANCHI, LEONARDO PEREIRA; TEDESCO, ANTONIO CLAUDIO. DNA polymeric films as a support for cell growth as a new material for regenerative medicine: Compatibility and applicability. Experimental Cell Research, v. 360, n. 2, p. 404-412, NOV 15 2017. (15/18684-9, 13/50181-1, 14/11870-9)

PELLOSI, DIOGO S.; PAULA, LEONARDO B.; DE MELO, MARYANNE T.; TEDESCO, ANTONIO C.. Targeted and Synergic Glioblastoma Treatment: Multifunctional Nanoparticles Delivering Verteporfin as Adjuvant Therapy for Temozolomide Chemotherapy. MOLECULAR PHARMACEUTICS, v. 16, n. 3, p. 1009-1024, MAR 2019. (13/50181-1, 16/00389-3, 18/24004-9, 15/18684-9)

DE PAULA, L. B.; PRIMO, F. L.; PINTO, M. R.; MORAIS, P. C.; TEDESCO, A. C.. Evaluation of a chloroaluminium phthalocyanine-loaded magnetic nanoemulsion as a drug delivery device to treat glioblastoma using hyperthermia and photodynamic therapy. RSC ADVANCES, v. 7, n. 15, p. 9115-9122, 2017. (15/18684-9, 13/50181-1)

PELLOSI, DIOGO SILVA; MACAROFF, PATRICIA PEREIRA; MORAIS, PAULO CESAR; TEDESCO, ANTONIO CLAUDIO. Magneto low-density nanoemulsion (MLDE): A potential vehicle for combined hyperthermia and photodynamic therapy to treat cancer selectively. Materials Science & Engineering C-Materials for Biological Applications, v. 92, p. 103-111, NOV 1 2018. (15/18684-9, 16/00389-3, 13/50181-1)

PELLOSI, DIOGO SILVA; CALORI, ITALO RODRIGO; DE PAULA, LEONARDO BARCELOS; HIOKA, NOBORU; QUAGLIA, FABIANA; TEDESCO, ANTONIO CLAUDIO. Multifunctional theranostic Pluronic mixed micelles improve targeted photoactivity of Verteporfin in cancer cells. Materials Science & Engineering C-Materials for Biological Applications, v. 71, p. 1-9, FEB 1 2017. (13/50181-1, 16/00389-3, 15/18684-9)