Evaluation of aldehyde dehydrogenase 1 and 2 in premalignant lesions and in oral squamous cell carcinoma

• Grant number: 15/17963-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2015
• End date: October 31, 2016
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Estela Kaminagakura Tango
• Grantee: Isabela Paladini
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil

Abstract

Epithelial dysplasia can be present any histological diagnosis of premalignant lesions clinically classified as leukoplakia, erythroplakia, eritholeukoplakia. This condition is associated with the risk of transformation into carcinoma. The oral squamous cell carcinoma is a malignant neoplasm that mainly affects smokers and alcoholic drinkers between the 5th and 6th decades of life. The objective of this study is to evaluate the protein expression of ALDH1 and ALDH2 in 30 premalignant lesions with epithelial dysplasia and compared them to 30 cases of OSCC. The results will be correlated with their clinical characteristics and prognosis. The variables between the groups will be compared using the x2 test or Fisher's exact test. The survival analysis will be evaluated by Kaplan-Meier method and Cox proportional hazards model.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COSTA, FERNANDA HERRERA; RIBEIRO EL ACHKAR, VIVIAN NARANA; COSTA, VICTOR; PALADINI, ISABELA; KOWALSKI, LUIZ PAULO; CARVALHO, YASMIN RODARTE; KAMINAGAKURA, ESTELA. Different Expression of Aldehyde Dehydrogenases 1A1 and 2 in Oral Leukoplakia With Epithelial Dysplasia and in Oral Squamous Cell Carcinoma. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v. 27, n. 7, p. 537-542, AUG 2019. (16/20103-7, 15/17963-1, 12/21660-6)

COSTA, FERNANDA HERRERA; RIBEIRO EL ACHKAR, VIVIAN NARANA; COSTA, VICTOR; PALADINI, ISABELA; KOWALSKI, LUIZ PAULO; CARVALHO, YASMIN RODARTE; KAMINAGAKURA, ESTELA. Different Expression of Aldehyde Dehydrogenases 1A1 and 2 in Oral Leukoplakia With Epithelial Dysplasia and in Oral Squamous Cell Carcinoma. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v. 27, n. 7, p. 6-pg., 2019-08-01. (12/21660-6, 15/17963-1, 16/20103-7)