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The acaricide action of Jambu (Acmella oleracea): I. Study of the effects on morphophysiology of male and female reproductive systems of Amblyomma cajennense (Fabricius, 1787) (Acari: Ixodidae)

Grant number: 15/01496-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2015
Effective date (End): May 31, 2019
Field of knowledge:Biological Sciences - Zoology
Principal Investigator:Maria Izabel Souza Camargo
Grantee:Luís Adriano Anholeto
Home Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil
Associated scholarship(s):18/08166-9 - Acaricidal activity in vitro of spilanthol against cell lines derived from acaricide-resistant and acaricide-susceptible Rhipicephalus microplus ticks with or without Ehrlichia minasensis infection, BE.EP.DR


Ticks are blood-sucking ectoparasites of great epidemiological importance, as are vectors of many pathogens to different species of animals, especially mammals, including man. The Amblyomma cajennense tick species, popularly known as the star tick or rodoleiro, has great medical importance mainly because it is vector of Rickettsia rickettsii, causing the Rocky Spotted Fever which can lead the host died. Man is heavily parasitized mainly by larval and nymphal tick. In an attempt to control tick infestations have been used chemical acaricides efficient in eliminating ectoparasites, however offer risks to humans, non-target organisms and the environment. Thus, there is the need to seek control these ectoparasites, with less environmentally damaging methods, to non- target organisms and human health. The use of acaricides products from plants has been shown to be extremely promising. In general, the plants products are presented as a potential alternative, and for this reason, the development of research focusing on compounds derived from plants may provide an environmentally safer products and more suitable than synthetic ones. Thus, this study aims to conduct a study on the action of the extract of the aerial parts (flower, leaf and stem) of Acmella oleracea (Asteraceae) on male and female reproductive systems of A. cajennese ticks. The extract of A. oleracea has proven acaricidal activity, and shown to be highly effective in engorged female and larvae of Rhipicephalus microplus (cattle tick), and is described in the literature as a product with an analgesic action, antifungal and insecticide. Therefore, experiments will be conducted to determine the lethal concentration and sublethal, morphophysiological analysis of the testes and oocytes by histology and immunohistochemistry techniques (Conventional Light Microscopy) analysis in Transmission Electron Microscopy and Confocal Laser Scanning. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANHOLETO, LUIS ADRIANO; DE OLIVEIRA, PATRICIA ROSA; FERREIRA RODRIGUES, RODNEY ALEXANDRE; YAMANE, LAIS THIEMI; DE CARVALHO CASTRO, KARINA NEOOB; CAMARGO-MATHIAS, MARIA IZABEL. Morphological alterations in the ovaries of Amblyomma cajennense semi-engorged ticks exposed to ethanolic extract of Acmella oleracea. MICROSCOPY RESEARCH AND TECHNIQUE, v. 81, n. 11, p. 1347-1357, NOV 2018. Web of Science Citations: 0.
ANHOLETO, LUIS ADRIANO; DE OLIVEIRA, PATRICIA ROSA; FERREIRA RODRIGUES, RODNEY ALEXANDRE; YAMANE, LAIS THIEMI; DE CARVALHO CASTRO, KARINA NEOOB; FERNANDES FERREIRA, ALLAN ROBERTO; CAMARGO-MATHIAS, MARIA IZABEL. Toxic action of Acmella oleracea extract on the male reproductive system of Amblyomma cajennense ticks. Veterinary Parasitology, v. 244, p. 164-171, SEP 15 2017. Web of Science Citations: 1.
ANHOLETO, LUIS ADRIANO; DE OLIVEIRA, PATRICIA ROSA; FERREIRA RODRIGUES, RODNEY ALEXANDRE; SPINDOLA, CAROLINE DOS SANTOS; LABRUNA, MARCELO BAHIA; PIZANO, MARCOS APARECIDO; DE CARVALDO CASTRO, KARINA NEOOB; CAMARGO-MATHIAS, MARIA IZABEL. Potential action of extract of Acmella oleracea (L.) RK Jansen to control Amblyomma cajennense (Fabricius, 1787) (Acari: Ixodidae) ticks. TICKS AND TICK-BORNE DISEASES, v. 8, n. 1, p. 65-72, 2017. Web of Science Citations: 6.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ANHOLETO, Luís Adriano. O jambu (Acmella oleracea) e sua ação acaricida : estudo dos efeitos sobre a morfofisiologia dos sistemas reprodutores masculino e feminino de Amblyomma cajennense (Fabricius, 1787) (Acari: Ixodidae) a ele expostos. 2019. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Rio Claro)..

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