Natural products and neglected diseases: chemical and biological study of crude extract and fractions obtained from Miconia ibaguensis (Melastomataceae)

• Grant number: 15/19093-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2015
• End date: October 31, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Wilson Roberto Cunha
• Grantee: Daniela Barbosa da Silva
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

This project aims at preparing the crude extract of the plant species Miconia ibaguensis, collected in the "cerrado" region. The obtained extract and fractions will be evaluated in vitro against the parasites that cause leishmaniasis (Leishmania amazonensis), schistosomiasis (Schistosoma mansoni) and Chagas' disease (Trypanosoma cruzi), thus seeking promising fractions for further fractionation and isolation of major constituents in order to obtain the possible active ingredients.