Patterns of cardiac hypertrophy in sever obesity according to the classification of obesity and the severity of sistemic arterial hypertension

• Grant number: 15/12265-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2015
• End date: September 30, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Roberto de Cleva
• Grantee: Victor Arrais Araujo
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Obesity is a multifactorial disease in which is verified a pathologic increase of adipose tissue associated with a low intensity chronic inflammatory state. Obesity is considered a worldwide epidemic disorder and represents one of the major challenges in public health due to its increase in prevalence and incidence, besides many complications and comorbidities associated. The systemic arterial hypertension (SAH) is one of the main comorbidities associated with obesity, 50% more prevalent in obese people. The left ventricular hypertrophy (LVH) is an extremely important risk factor for cardiovascular morbidity and mortality and it is the center of many studies that correlate the cardiac hypertrophy with hypertension and with obesity. The LVH is often divided into two groups: concentric or eccentric. The concentric hypertrophy is observed when left ventricle is submitted to an overload pressure due to a persistent increase in afterload. The eccentric hypertrophy is traditionally associated with a volumetric overload and it is, therefore, related to obesity since it establishes a chronic estate of volumetric overload in order to maintain the blood flowing through the excessive adipose tissue deposit. It is believed that the combination of hypertension and obesity provides a superior additive effect to the mechanism of hypertrophy than each by their own. However it is unclear which one is the main responsible in sever obesity. The purpose of this study is to correlate the patterns of cardiac hypertrophy in sever obesity according to the classification of obesity and severity of the systemic arterial hypertension.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE CLEVA, ROBERTO; ARAUJO, VICTOR ARRAIS; ORNELAS BUCHALLA, CARLA CRISTINA; COSTA, FABIO DE OLIVEIRA; CARDOSO, ACACIO FERNANDES; PAJECKI, DENIS; SANTO, MARCO AURELIO. Cardiac Remodeling Patterns in Severe Obesity According to Arterial Hypertension Grade. OBESITY SURGERY, v. 28, n. 4, p. 1047-1054, APR 2018. (15/12265-4)