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Grant number: 15/17155-2
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2015
Effective date (End): May 31, 2018
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:Guilherme de Camargo Ferraz
Grantee:Mayara Goncalves Fonseca
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil


Considering the national importance of Mangalarga Marchador (MM) breed and its increasing internationalization, studies evaluating different aspects of their unique gaits - marcha batida (MB) and marcha picada (MP) - are needed. The objectives of this study are to determine the kinematic variables (VCine) of MB and MP of previously awarded horses; to verify associations between morphometric measurements and VCine; to verify the differences in VCine between MM horses with homozygous and heterozygous genotypes for the DMRT3 gene for each type of gait; and to identify, through large genome-wide association study (GWAS), SNPs and genomic regions containing possible genes responsible for the phenotype of MB in MM breed. 12 horses of each gender and each gait (total 48 horses) will have 35 morphometric measurements assessed and 23 VCine determined by three-dimensional system. The MB and the MP will be compared by unpaired Student's t test (Pd0.05) and associations between morphometry and kinematics will be evaluated by Pearson correlation. The SNP g.22999655C>A of DMRT3 equine gene will be analyzed by genotyping protocol by PCR-RFLP technique and correlated with VCine. The DNA samples from each individual will be genotyped with Equine SNP70 BeadChip. Association study will be performed using the Cochran-Armitage test with 1 degree of freedom implemented by Plink software v1.07. Positions of SNPs and genes will be considered based on the latest assembly sequence of the horse genome (EquCab2.0 available on the National Center database for Biotechnology Information -NCBI).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FONSECA, MAYARA GONCALVES; FERRAZ, GUILHERME DE CAMARGO; LAGE, JESSICA; PEREIRA, GUILHERME LUIS; CURI, ROGERIO ABDALLAH. A Genome-Wide Association Study Reveals Differences in the Genetic Mechanism of Control of the Two Gait Patterns of the Brazilian Mangalarga Marchador Breed. Journal of Equine Veterinary Science, v. 53, p. 64-67, JUN 2017. Web of Science Citations: 7.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FONSECA, Mayara Goncalves. Mangalarga Marchador : estudo morfométrico, cinemático e genético da marcha batida e da marcha picada. 2018. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Agrárias e Veterinárias..

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