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Characterization of intestinal microbiota of patients with colorectal cancer and its possible association with human papillomavirus

Grant number: 15/07526-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2015
Effective date (End): October 31, 2016
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal Investigator:Adhemar Longatto Filho
Grantee:Marina Ignácio Gonzaga
Home Institution: Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brazil

Abstract

For years, few studies have evaluated the microorganisms that live harmoniously in the skin and mucosal surfaces of human host, referred to as microbiote. Usually this microbiote does not stimulate inflammatory immune responses due to the co-evolution of immunity and commensal organisms, maintaining intestinal homeostasis. However, when this balance is broken, a process called dysbiosis, pathogenic bacteria or other microorganisms such as viruses, are introduced in the environment; thus, the immune system activated, can trigger and promote tumorigenesis in the intestine.Colorectal cancer is the third main type of highest incidence worldwide and its development is influenced by genetic and environmental factors, dietetic habits and lifestyle. Therefore, understanding the contribution of these various factors may provide tools to prevent or control the development of this pathology.Human papillomavirus infects mucosa and skin, providing necessary factor for the development of cervical cancer mainly, but has also been associated with the development of adenocarcinoma of the colon. Thus, it is believed that a positive relation can be established among dysbiosis, human papillomavirus and development of colorectal cancer. Furthermore, the microbiote isolated from patients with colorectal cancer is different to that obtained from healthy subjects and this can result in a difference in the detected cytokine profile and disease behavior observed.So this project observational case-control with collecting prospective of samples, we intend to correlate the composition and quantification of intestinal microbiote with clinical and sociodemographic data and high risk- papillomavirus DNA presence.