| Grant number: | 15/16601-9 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | December 01, 2015 |
| End date: | November 30, 2017 |
| Field of knowledge: | Health Sciences - Nutrition - Nutrition Biochemistry |
| Principal Investigator: | Fernando Moreira Simabuco |
| Grantee: | Fernando Riback Silva |
| Host Institution: | Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil |
| Associated research grant: | 12/13558-7 - Molecular characterization of S6Ks in obesity and its associated diseases, AP.JP |
Abstract The mTOR signaling pathway has been linked to various diseases and metabolic disorders in humans, including obesity, diabetes and several types of cancer. The S6Ks proteins have shown important role in signaling mTOR, functioning as effectors of this pathway, but some of their functional differences and interacting target proteins are still open questions. The family of S6Ks is composed of two genes, S6K1 and S6K2, and has the following isoforms: p70-S6K1, p85-S6K1 and p54-S6K2. The aim of this study is to investigate the possible interaction between nucleophosmin (NPM1) and nucleolin (NCL), involved in ribosome synthesis, with S6Ks. Data obtained previously showed that the p70-S6K1 and p54-S6K2 overexpressed in human cells were immunoprecipitated and able to co-immunoprecipitate the proteins focus of this study, NPM1 and NCL. It is known that these two proteins of interest are directly linked to cell proliferation, ribosome biogenesis and protein synthesis, and thus it is expected that this study may elucidate new action mechanisms of S6Ks on these important biological processes. | |
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