STUDY OF ADVERSE REACTIONS , QUALITY OF LIFE AND CELLULAR OXIDATIVE STRESS IN HEAD AND NECK CANCER PATIENTS IN TREATMENT WITH CISPLATIN AND RADIOTHERAPY

• Grant number: 15/01793-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: December 01, 2015
• End date: February 28, 2017
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Patricia Moriel
• Grantee: Júlia Coelho França Quintanilha
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Head and neck cancer corresponds to tumors located in the upper aerodigestive tract, such as the oral cavity, pharynx and larynx. The most effective treatment consists of high doses of cisplatin chemotherapy and radiotherapy, however, their use is limited due to toxicities caused mainly by oxidative stress. The objective of this study will be evaluate the toxicities caused by cellular oxidative stress in head and neck cancer patients treated with cisplatin. This is an observational prospective quantitative clinical trial with consecutive sampling that will be conducted at Oncology Department of Clinic Hospital / UNICAMP. Head and neck cancer patients who will begin cisplatin antineoplastic treatment (80-100mg/m2 on days 1, 22 and 43) and concurrent radiotherapy will be included in this research. It will be evaluated cisplatin induced hematologic and gastrointestinal disorders, nephrotoxicity, ototoxicity, and hepatotoxicity; cellular oxidative stress will be measured by Amplex Red, MitoSOX Red and Oxidized/Reduced Glutathione tests. Results will be statistically analyzed using Chi-square, Fisher's exact, Mann-Whitney, and ANOVA for repeated measures tests, considering p<0.05.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VISACRI, MARILIA B.; QUINTANILHA, JULIA C. F.; DE SOUSA, VANESSA M.; AMARAL, LAIS S.; AMBROSIO, ROSIANE DE F. L.; CALONGA, LUCIANE; CURI, SILVIA F. B. B.; LEME, MAYRA F. DE T.; CHONE, CARLOS T.; ALTEMANI, JOAO M. C.; et al. Can acetylcysteine ameliorate cisplatin-induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double-blind, placebo-controlled trial involving patients with head and neck cancer. CANCER MEDICINE, v. 8, n. 5, p. 2020-2030, MAY 2019. (17/17728-8, 14/04744-7, 14/18294-3, 15/01793-0)

QUINTANILHA, JULIA C. F.; VISACRI, MARILIA B.; SOUSA, VANESSA M.; BASTOS, LARISSA B.; VAZ, CAMILA O.; GUARNIERI, JOAO P. O.; AMARAL, LAIS S.; MALAGUTI, CARINA; LIMA, CARMEN S. P.; VERCESI, ANIBAL E.; et al. Cisplatin-induced human peripheral blood mononuclear cells' oxidative stress and nephrotoxicity in head and neck cancer patients: the influence of hydrogen peroxide. Molecular and Cellular Biochemistry, v. 440, n. 1-2, p. 139-145, MAR 2018. (15/01793-0, 14/18294-3)

FRANCA QUINTANILHA, JULIA COELHO; VISACRI, MARILIA BERLOFA; AMARAL, LAIS SAMPAIO; PASSOS LIMA, CARMEN SILVIA; CINTRA, MARIA LETICIA; MORIEL, PATRICIA. Leukocytoclastic vasculitis complicating cisplatin plus radiation treatment for laryngeal cancer: a case report. BMC CANCER, v. 17, DEC 6 2017. (14/04744-7, 14/18294-3, 15/01793-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

QUINTANILHA, Júlia Coelho França. Evaluation of adverse reactions, quality of life and cellular oxidative stress in patients with head and neck cancer in treatment with cisplatin and radiotherapy. 2017. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.