Evaluation of adverse reactions, quality of life and cellular oxidative stress in patients with head and neck cancer in treatment with cisplatin and radiotherapy

Author(s)

Júlia Coelho França Quintanilha

• Document type: Master's Dissertation
• Press: Campinas, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas
• Defense date: 2017-02-07

Examining board members

Patricia Moriel; Leonardo Régis Leira Pereira; Priscila Gava Mazzola

• Advisor: Patricia Moriel

Abstract

Head and neck cancer tumors are located in the upper aerodigestive tract. The most effective treatment consists of radiotherapy concomitant with chemotherapy using cisplatin, however, its use is limited due to its toxicity mainly caused by oxidative stress. The aim of this study was to evaluate the adverse reactions, quality of life and the cellular oxidative stress in patients with head and neck cancer treated with cisplatin and radiotherapy. This is an analytical, experimental, clinical, single arm, prospective, quantitative study whose non-probabilistic sampling was of the consecutive type, performed at HC / UNICAMP. Patients with head and neck cancer treated with cisplatin (80-100 mg/m2 every 21 days) and radiotherapy were included in this study. Adverse reactions were assessed and classified based on severity, according to the Common Toxicity Criteria. Cellular oxidative stress was measured by Amplex Red, MitoSox Red, H2DCF-DA tests and determination of total glutathione. The quality of life was measured by applying the questionnaires of the European Organization for Research and Treatment of Cancer Quality of Life. Twenty-four patients were evaluated after the first cycle of chemotherapy, with a mean age of 55,42 ± 7,81 years. H2O2 was associated with renal and hematologic adverse reactions; O2?- with hepatic and hematologic reactions; reactive species of oxygen and nitrogen in general with hematological reactions; and total glutathione was correlated with hepatic and hematologic reactions. Patients¿ quality of live was reduced in some domains and improved regading to pain. Therefore, this work emphasizes the reactions induced by cisplatin and the role of oxidative stress in nephrotoxicity, hematotocixity and hepatotoxicity (AU)

• FAPESP's process: 15/01793-0 - STUDY OF ADVERSE REACTIONS , QUALITY OF LIFE AND CELLULAR OXIDATIVE STRESS IN HEAD AND NECK CANCER PATIENTS IN TREATMENT WITH CISPLATIN AND RADIOTHERAPY
• Grantee: Júlia Coelho França Quintanilha
• Support Opportunities: Scholarships in Brazil - Master