Study of TGF-²1 in differentiated thyroid carcinoma

• Grant number: 15/19117-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: January 01, 2016
• End date: December 31, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Laura Sterian
• Grantee: Karina Colombera Peres
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Thyroid nodules are extremely frequent, affecting approximately 50% of population. While common, the majority of detectable nodules are benign. While common, the majority of detectable lumps are benign. However, 25% of these do not have a conclusive diagnosis by cytology, hindering the clinical approach to these patients. The transforming growth factor-² (TGF-²) is a cytokine involved in proliferation, migration, inflammation, tissue repair, immune response, cellular differentiation and apoptosis in different cell types. The TGF-² primary function is to mediate intracellular activation of pro-inflammatory cytokines and deficiency leads to an extensive inflammation. Our group has shown that inflammation may be related to the molecular profile and the CDT prognosis. The objective of this study is to test a possible correlation between polymorphisms in TGFB1 genes and their receptors (TGFBR1 and TGFBR2) and its gene and protein expression, and susceptibility to differentiated thyroid cancer (DTC) and/or the characteristics clinical disease and its progression. Will be analyzed 100 patients with DTC and 100 patients with benign nodules. The data obtained will be related to clinical data and patient outcomes. This will be associated with data obtained in previous studies on immunological aspects of the response to tumor, including cytokines and their receptors. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KARINA COLOMBERA PERES; LARISSA TEODORO; LAÍS HELENA PEREIRA AMARAL; ELISÂNGELA SOUZA TEIXEIRA; ICLÉIA SIQUEIRA BARRETO; LEANDRO LUIZ LOPES DE FREITAS; VALDEMAR MAXIMO; LÍGIA V. MONTALLI ASSUMPÇÃO; NATASSIA ELENA BUFALO; LAURA STERIAN WARD. Clinical utility of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules: evaluation based on single nucleotide polymorphisms and mRNA analysis. ARCHIVES OF ENDOCRINOLOGY METABOLISM, n. ahead, p. -, 2021. (15/19117-0)

KARINA COLOMBERA PERES; LARISSA TEODORO; LAÍS HELENA PEREIRA AMARAL; ELISÂNGELA SOUZA TEIXEIRA; ICLÉIA SIQUEIRA BARRETO; LEANDRO LUIZ LOPES DE FREITAS; VALDEMAR MAXIMO; LÍGIA V. MONTALLI ASSUMPÇÃO; NATASSIA ELENA BUFALO; LAURA STERIAN WARD. Clinical utility of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules: evaluation based on single nucleotide polymorphisms and mRNA analysis. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 65, n. 2, p. 172-184, 2021-03-05. (15/19117-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PERES, Karina Colombera. Study of TGF-ß1 in the differentiated thyroid carcinoma. 2018. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.