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Synthesis and characterization of bioconjugates containing peptides with antitumor activity

Grant number: 15/23095-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2016
Effective date (End): December 31, 2016
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Eduardo Maffud Cilli
Grantee:Danyelle Trevisan de Macedo Dias
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated research grant:13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery, AP.CEPID

Abstract

Due to the low therapeutic index of cancer treatment, various researches have been conducted for the development of methods/molecules that allow cheaper therapies, faster and less uncomfortable for patients with the disease. In this project, a peptide aptamer, an antimicrobial peptide and a thiosemicarbazone be used as molecules in the development of bioconjugates, in order to increase the specificity and anti-tumor activity of these compounds. In this context, thiosemicarbazone and antimicrobial peptide will be used as antitumor compounds, while the peptide aptamer is responsible for promoting specificity against the tumor cells. For the development of this project, the following methods will be used: peptide solid phase synthesis, purification and characterization of the peptides by high-performance liquid chromatography (HPLC/HPLC), mass spectrometry test of viability/cell proliferation and microscopy. We expect this work to develop anticancer molecules with high specificity and activity.